Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 13/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635902 | 0.98 | LTA4H (0.46) | LTA4HCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9343894 | 0.82 | KDM4E (0.38) | LTA4HHTTL3MBTL1KDM4E | |
| SCHEMBL6767445 | 0.75 | LTA4H (0.57) | LTA4HCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9056397 | 0.74 | G6PC1 (0.41) | LTA4HL3MBTL1MEN1KMT2AUSP2 | |
| SCHEMBL8808702 | 0.74 | AGER (0.53) | MEN1KMT2AUSP2HPGDHSD17B10 | |
| SCHEMBL2130214 | 0.72 | LTA4H (0.48) | LTA4HCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8809140 | 0.71 | PSEN1 (0.42) | LTA4HMEN1KMT2A | |
| SCHEMBL27949438 | 0.70 | HRH1 (0.73) | LTA4HHRH1KDM4EMEN1ALDH1A1 | |
| SCHEMBL27323330 | 0.69 | SLC18A3 (0.45) | L3MBTL1ALDH1A1USP2HPGDHSD17B10 | |
| SCHEMBL3375958 | 0.67 | GRIN2B (0.60) | LTA4HL3MBTL1KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |