Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 3/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640706 | 0.87 | ALDH1A1 (0.40) | PPARAMMP1MMP2MMP13L3MBTL1 | |
| SCHEMBL8641923 | 0.87 | ELANE (0.42) | PPARALTA4HLMNAPPARGS1PR1 | |
| SCHEMBL8639942 | 0.83 | S1PR1 (0.43) | PPARALTA4HPPARGS1PR1S1PR3 | |
| SCHEMBL8639342 | 0.80 | ELANE (0.43) | PPARALTA4HLMNAPPARGS1PR1 | |
| SCHEMBL8640088 | 0.74 | ELANE (0.45) | PPARALTA4HKMT2AMEN1LMNA | |
| SCHEMBL8644289 | 0.73 | PPARA (0.74) | PPARALTA4HPPARG | |
| SCHEMBL8641651 | 0.72 | PPARA (0.68) | PPARALTA4HMMP1MMP2MMP13 | |
| SCHEMBL27996167 | 0.71 | LTA4H (0.48) | LTA4HMMP1NPC1RAB9AALDH1A1 | |
| SCHEMBL644718 | 0.71 | RIPK1 (0.44) | PPARAL3MBTL1NPC1RAB9AALDH1A1 | |
| SCHEMBL1960388 | 0.70 | ELANE (0.49) | L3MBTL1NPC1RAB9AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |