Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 13/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 4/20 | 0.36 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11068228 | 0.74 | OPRK1 (0.78) | OPRK1LTA4HALDH1A1RECQLMMP8 | |
| SCHEMBL8637712 | 0.72 | PPARG (0.40) | OPRK1LTA4HPPARAPPARG | |
| SCHEMBL27556624 | 0.71 | PIN1 (0.43) | OPRK1ALDH1A1RECQLMMP8PPARA | |
| SCHEMBL11066953 | 0.70 | OPRK1 (0.63) | OPRK1LTA4HALDH1A1RECQLMMP8 | |
| SCHEMBL11459021 | 0.69 | OPRK1 (0.54) | OPRK1LTA4HPPARAPPARG | |
| SCHEMBL5205608 | 0.69 | LMNA (0.51) | ALDH1A1PPARG | |
| SCHEMBL20240288 | 0.66 | SCN9A (0.51) | LTA4HMMP8PPARAPPARG | |
| SCHEMBL7491986 | 0.66 | SLC7A5 (0.54) | LTA4HALDH1A1MMP8PPARAPPARG | |
| SCHEMBL28851706 | 0.65 | MAPT (0.46) | ALDH1A1PPARAPPARGHTR2A | |
| Hydrochloric Acid SCHEMBL7491967 | 0.65 | SLC7A5 (0.53) | LTA4HMMP8PPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |