Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.40 |
| ▸ | PPARA | Q07869 | 4/20 | 0.40 |
| ▸ | LTA4H | P09960 | 13/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8644119 | 0.75 | PPARG (0.47) | PPARGPPARALTA4HLMNAL3MBTL1 | |
| SCHEMBL8639364 | 0.74 | PPARG (0.44) | PPARGPPARALTA4HLMNAL3MBTL1 | |
| SCHEMBL8639512 | 0.72 | OPRK1 (0.46) | PPARGPPARALTA4HOPRK1 | |
| SCHEMBL11066953 | 0.71 | OPRK1 (0.63) | PPARGPPARALTA4HLMNAOPRK1 | |
| SCHEMBL8639342 | 0.66 | ELANE (0.43) | PPARGPPARALTA4HLMNAOPRK1 | |
| SCHEMBL11068228 | 0.66 | OPRK1 (0.78) | PPARGPPARALTA4HLMNAOPRK1 | |
| SCHEMBL8639571 | 0.65 | LTA4H (0.44) | LTA4HLMNAL3MBTL1 | |
| SCHEMBL8635978 | 0.64 | LTA4H (0.43) | PPARGPPARALTA4HLMNA | |
| SCHEMBL8640502 | 0.64 | LTA4H (0.43) | PPARGPPARALTA4H | |
| SCHEMBL8641923 | 0.63 | ELANE (0.42) | PPARGPPARALTA4HLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |