SCHEMBL8640306

SCHEMBL8640306

CC(=O)OC(CCl)c1ccsc1S(=O)(=O)NC(C)(C)C

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
POLB P06746 1/20 0.34
THRB P10828 1/20 0.34
RECQL P46063 1/20 0.34
KMT2A Q03164 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
ADRB2 P07550 1/20 0.31
ADRB1 P08588 1/20 0.31
CA9 Q16790 1/20 0.31
AR P10275 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8637572 0.88 KDM4E (0.32) KDM4EMEN1ALDH1A1LMNAPOLB
SCHEMBL8637540 0.82 CA2 (0.33) CA12CA1CA2CA9
SCHEMBL9021059 0.79 ALDH1A1 (0.34) KDM4EMEN1ALDH1A1LMNAPOLB
SCHEMBL9021100 0.76 USP30 (0.32) KDM4EMEN1ALDH1A1LMNAPOLB
SCHEMBL9259502 0.74 USP30 (0.35) KDM4EALDH1A1POLBCA12CA1
SCHEMBL8642351 0.73 GAA (0.48) KDM4EMEN1ALDH1A1KMT2ASMN1; SMN2
SCHEMBL8636612 0.72 LMNA (0.35) KDM4EMEN1ALDH1A1LMNAPOLB
SCHEMBL8642688 0.70 GSK3B (0.40) KDM4EMEN1ALDH1A1LMNAPOLB
SCHEMBL8640193 0.69 CA2 (0.33) CA12CA1CA2CA9
SCHEMBL9020663 0.68 ALDH1A1 (0.35) KDM4EMEN1ALDH1A1LMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5726127-A Thiophenesulfonylurea derivatives and herbicidal composition containing the same KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1998-03-10 US disclosed
EP-0728133-A1 NOVEL THIOPHENESULFONYLUREA DERIVATIVES AND HERBICIDAL COMPOSITION CONTAINING THE SAME KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1996-08-28 EP disclosed