Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 4/20 | 0.43 |
| ▸ | RARG | P13631 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8636450 | 0.91 | KMT2A (0.48) | RORCRARGCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4794842 | 0.80 | ATM (0.42) | RORCRARGCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL30315729 | 0.79 | L3MBTL1 (0.43) | KDM4EL3MBTL1ALDH1A1PTGS2MAPK1 | |
| SCHEMBL26074810 | 0.79 | L3MBTL1 (0.43) | KDM4EL3MBTL1ALDH1A1PTGS2MAPK1 | |
| SCHEMBL8637313 | 0.77 | RORC (0.52) | KDM4EL3MBTL1RORCRARGALDH1A1 | |
| SCHEMBL2069985 | 0.76 | CYP1A2 (0.49) | L3MBTL1CYP1A2ALDH1A1KMT2AMEN1 | |
| SCHEMBL8637494 | 0.76 | RORC (0.49) | KDM4ERORCRARGCYP1A2ALDH1A1 | |
| SCHEMBL11945535 | 0.76 | ALDH1A1 (0.60) | KDM4EL3MBTL1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL8830115 | 0.76 | RORC (0.44) | KDM4ERORCRARGLMNA | |
| SCHEMBL9338844 | 0.75 | NPBWR1 (0.44) | KDM4EL3MBTL1CYP3A4CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519140-B1 | Method for the preparation of substituted 1,4-dihydro-4-oxo-cinnoline-3-carboxylic acids, esters and salts thereof, and intermediates used in this method | HYBRINOVA (FR) | 1998-07-29 | — | — | EP | disclosed |
| US-5304672-A | Intermediates for pollen suppressants | ORSAN (FR) | 1994-04-19 | — | — | US | disclosed |
| US-5183891-A | Method for the preparation of substituted 1,4-dihydro-4-oxo-cinnoline-3-carboxylic acid, esters and salts thereof, and intermediates used in their preparation | ORSAN (FR) | 1993-02-02 | — | — | US | disclosed |
| EP-0519140-A1 | Method for the preparation of substituted 1,4-dihydro-4-oxo-cinnoline-3-carboxylic acid, esters and salts thereof, and intermediates used in their preparation | HYBRINOVA (FR) | 1992-12-23 | — | — | EP | disclosed |