Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.30 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.30 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8644118 | 0.85 | LTA4H (0.39) | LTA4HELANEOPRK1PPARAPPARG | |
| SCHEMBL8641132 | 0.81 | LTA4H (0.42) | LTA4HPTGS1PTGS2TRPM8CYP1A2 | |
| SCHEMBL8637371 | 0.78 | LTA4H (0.39) | LTA4HELANEOPRK1PTGS1PTGS2 | |
| SCHEMBL8907701 | 0.74 | PPARA (0.40) | LTA4HPPARAPPARGALDH1A1 | |
| SCHEMBL8640502 | 0.70 | LTA4H (0.43) | LTA4HELANEPTGS1PTGS2TRPM8 | |
| SCHEMBL8637374 | 0.68 | LTA4H (0.43) | LTA4HELANEOPRK1PTGS1PTGS2 | |
| SCHEMBL14431994 | 0.68 | S1PR4 (0.43) | ELANES1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL11335723 | 0.65 | LTA4H (0.46) | LTA4HELANEOPRK1S1PR1S1PR3 | |
| SCHEMBL27718547 | 0.64 | L3MBTL1 (0.50) | SIRT5CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL1855435 | 0.64 | LTA4H (0.57) | LTA4HALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | claimed |
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |