Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 6/20 | 0.40 |
| ▸ | PPARG | P37231 | 6/20 | 0.40 |
| ▸ | PPARD | Q03181 | 5/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | FPR2 | P25090 | 2/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8644118 | 0.79 | LTA4H (0.39) | PPARAPPARGLTA4H | |
| SCHEMBL8640499 | 0.74 | LTA4H (0.41) | PPARAPPARGALDH1A1LTA4H | |
| SCHEMBL8641132 | 0.73 | LTA4H (0.42) | ALDH1A1SMN1; SMN2RIPK1LTA4H | |
| SCHEMBL14433010 | 0.68 | MMP9 (0.42) | PPARAPPARDMMP13MMP9ALDH1A1 | |
| SCHEMBL19262085 | 0.67 | CYP1A2 (0.37) | PPARAPPARGPPARDALDH1A1RIPK1 | |
| SCHEMBL14431994 | 0.67 | S1PR4 (0.43) | PPARAPPARGALDH1A1SMN1; SMN2 | |
| SCHEMBL5533571 | 0.66 | PPARA (0.40) | PPARAPPARGPPARDSMN1; SMN2 | |
| SCHEMBL22967388 | 0.66 | NPC1 (0.41) | PPARAPPARGPPARDMMP13MMP1 | |
| SCHEMBL11548438 | 0.65 | ADORA3 (0.48) | PPARAPPARGPPARDALDH1A1 | |
| SCHEMBL21991259 | 0.65 | POLB (0.47) | PPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | claimed |