Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP9X | Q93008 | 5/20 | 0.48 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.48 |
| ▸ | USP5 | P45974 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL864058 | 1.00 | USP9X (0.48) | USP9XUCHL1USP5MCL1ALDH1A1 | |
| SCHEMBL6217606 | 0.88 | ALDH1A1 (0.52) | MCL1ALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL13051427 | 0.83 | RIPK1 (0.50) | MCL1ALDH1A1KDM4ELMNATACR3 | |
| SCHEMBL3753174 | 0.83 | RIPK1 (0.50) | MCL1ALDH1A1KDM4ELMNATACR3 | |
| SCHEMBL6323327 | 0.81 | ALDH1A1 (0.66) | MCL1ALDH1A1SMN1; SMN2HTTNCOA1 | |
| SCHEMBL863580 | 0.79 | ACACB (0.45) | SMN1; SMN2 | |
| SCHEMBL15093362 | 0.79 | TACR3 (0.51) | USP9XUCHL1USP5ALDH1A1KDM4E | |
| SCHEMBL574487 | 0.79 | TACR3 (0.51) | USP9XUCHL1USP5ALDH1A1KDM4E | |
| SCHEMBL2262924 | 0.78 | MAPT (0.58) | MCL1ALDH1A1POLBSMN1; SMN2HTT | |
| SCHEMBL12389348 | 0.78 | MAPT (0.58) | MCL1ALDH1A1POLBSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055310-B1 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | UNIV MICHIGAN REGENTS (US) | 2021-03-31 | — | — | EP | disclosed |
| EP-2619184-B1 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | UNIV MICHIGAN REGENTS (US) | 2018-05-23 | — | — | EP | disclosed |
| US-9868736-B2 | Deubiquitinase inhibitors and methods for use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-01-16 | — | — | US | disclosed |
| US-20160237082-A1 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2016-08-18 | — | — | US | disclosed |
| US-20140357673-A1 | Deubiquitinase Inhibitors and Methods for Use of the Same | UNIV MICHIGAN (US) | 2014-12-04 | — | — | US | disclosed |
| US-8809377-B2 | Deubiquitinase inhibitors and methods for use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-08-19 | — | — | US | disclosed |
| US-20120077806-A1 | Deubiquitinase Inhibitors and Methods for Use of the Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160237082-A1 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | USP1, UCHL1, USP2 | USP9X 33/4885UCHL1 2/4885USP5 14/4885 |
| US-20140357673-A1 | Deubiquitinase Inhibitors and Methods for Use of the Same | UCHL1, USP2, USP1 | USP9X 33/4885UCHL1 1/4885USP5 19/4885 |
| US-20120077806-A1 | Deubiquitinase Inhibitors and Methods for Use of the Same | UCHL1, USP2, USP1 | USP9X 33/4885UCHL1 1/4885USP5 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.