Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 14/20 | 0.42 |
| ▸ | BCHE | P06276 | 11/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637479 | 0.84 | ACHE (0.38) | ACHEBCHEOPRM1OPRD1OPRK1 | |
| SCHEMBL9004593 | 0.83 | LMNA (0.46) | — | |
| SCHEMBL9171923 | 0.81 | ROCK2 (0.44) | — | |
| SCHEMBL8640678 | 0.79 | LMNA (0.39) | — | |
| SCHEMBL8638136 | 0.76 | ACHE (0.38) | ACHEBCHEOPRM1OPRD1OPRK1 | |
| SCHEMBL8643444 | 0.74 | MAOB (0.44) | — | |
| SCHEMBL9174102 | 0.74 | CYP19A1 (0.39) | — | |
| SCHEMBL8981074 | 0.73 | LMNA (0.39) | — | |
| SCHEMBL9169246 | 0.72 | MAOB (0.38) | — | |
| SCHEMBL29329861 | 0.72 | ACHE (0.49) | ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0566018-B1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO SPA (IT) | 1998-08-05 | — | — | EP | disclosed |
| US-5480882-A | Benzoxazinone and benzothiazinone derivatives having cardiovascular activity | ITALFARMACO S.P.A. (IT) | 1996-01-02 | — | — | US | disclosed |
| EP-0566018-A2 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO S.p.A. (IT) | 1993-10-20 | — | — | EP | disclosed |