Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 13/20 | 0.38 |
| ▸ | BCHE | P06276 | 11/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637479 | 0.93 | ACHE (0.38) | ACHEBCHEMGLLOPRM1OPRD1 | |
| SCHEMBL8640361 | 0.83 | PLCG1 (0.40) | ALDH1A1SMN1; SMN2OPRM1OPRD1 | |
| SCHEMBL8639190 | 0.81 | LMNA (0.35) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL8658972 | 0.81 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL8636623 | 0.79 | CASP6 (0.41) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL6436979 | 0.78 | ALDH1A1 (0.36) | ACHEALDH1A1SMN1; SMN2 | |
| SCHEMBL8637170 | 0.78 | MAPT (0.35) | ALDH1A1 | |
| SCHEMBL8635721 | 0.78 | HPGD (0.39) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL8638962 | 0.77 | SMN1; SMN2 (0.36) | ALDH1A1SMN1; SMN2OPRM1OPRD1 | |
| SCHEMBL9004558 | 0.77 | LMNA (0.41) | ACHEALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5480882-A | Benzoxazinone and benzothiazinone derivatives having cardiovascular activity | ITALFARMACO S.P.A. (IT) | 1996-01-02 | — | — | US | claimed |
| EP-0566018-B1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO SPA (IT) | 1998-08-05 | — | — | EP | disclosed |
| US-5480882-A | Benzoxazinone and benzothiazinone derivatives having cardiovascular activity | ITALFARMACO S.P.A. (IT) | 1996-01-02 | — | — | US | disclosed |
| EP-0566018-A2 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO S.p.A. (IT) | 1993-10-20 | — | — | EP | disclosed |