Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8644129 | 0.88 | LMNA (0.41) | SPHK2SPHK1CARM1PRMT6LTA4H | |
| SCHEMBL8636128 | 0.87 | MAOB (0.56) | MAOAMAOBSPHK2SPHK1 | |
| SCHEMBL8641109 | 0.86 | LTA4H (0.52) | SPHK2SIGMAR1LTA4HALDH1A1ADRA1A | |
| SCHEMBL8638269 | 0.86 | LTA4H (0.50) | SPHK2SPHK1SIGMAR1CARM1PRMT6 | |
| SCHEMBL8637445 | 0.83 | HRH1 (0.46) | SIGMAR1LTA4HHRH1HRH3 | |
| SCHEMBL8639270 | 0.80 | LTA4H (0.44) | SPHK2SPHK1SIGMAR1CARM1PRMT6 | |
| SCHEMBL8640950 | 0.80 | SCN3A (0.43) | SPHK2SPHK1LTA4HALDH1A1SMN1; SMN2 | |
| SCHEMBL8637439 | 0.79 | LTA4H (0.50) | SIGMAR1TMEM97DRD4LTA4HALDH1A1 | |
| SCHEMBL8641764 | 0.79 | HRH3 (0.50) | SPHK2SPHK1SIGMAR1LTA4HHRH3 | |
| SCHEMBL8642301 | 0.78 | FAAH (0.44) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |