Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.45 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | CPB1 | P15086 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641654 | 1.00 | CTSL (0.46) | CTSLCTSBCTSKNAAATGM2 | |
| SCHEMBL13547350 | 0.81 | SMN1; SMN2 (0.47) | CTSLCTSBCTSKNAAATGM2 | |
| SCHEMBL5692127 | 0.76 | CTSL (0.67) | CTSLCTSBCTSKTGM2ALDH1A1 | |
| SCHEMBL949589 | 0.75 | CTSK (0.43) | CTSLCTSBCTSKALDH1A1TSHR | |
| SCHEMBL949590 | 0.75 | CTSK (0.43) | CTSLCTSBCTSKALDH1A1TSHR | |
| SCHEMBL8764157 | 0.74 | KAT2B (0.46) | CTSLCTSBCTSKALDH1A1PREP | |
| SCHEMBL6199732 | 0.74 | CASP3 (0.60) | CTSLCTSBCTSKALDH1A1GAA | |
| SCHEMBL5122686 | 0.73 | TGM2 (0.67) | CTSLCTSBCTSKTGM2ALDH1A1 | |
| SCHEMBL11031828 | 0.73 | TSHR (0.52) | CTSLCTSBCTSKNAAAALDH1A1 | |
| SCHEMBL11031824 | 0.73 | TSHR (0.52) | CTSLCTSBCTSKNAAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847135-A | Inhibitors of interleukin-1β converting enzyme | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 1998-12-08 | — | — | US | disclosed |
| US-5716929-A | THERAPY FOR INFLAMMATION, AUTOIMMUNE DISEASES | VERTEX PHARMACEUTICALS, INC. (US) | 1998-02-10 | — | — | US | disclosed |