SCHEMBL864359

SCHEMBL864359

NCCCNS(=O)(=O)C(F)(F)F

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 1/20 0.59
CA2 P00918 6/20 0.43
CA1 P00915 4/20 0.43
CA7 P43166 2/20 0.38
CA13 Q8N1Q1 1/20 0.38
CNR1 P21554 1/20 0.37
CNR2 P34972 1/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
HTT P42858 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
RELA Q04206 4/20 0.36
CASP2 P42575 2/20 0.35
CA12 O43570 1/20 0.35
F13A1 P00488 1/20 0.35
CYP1A2 P05177 1/20 0.35
ALOX15 P16050 1/20 0.35
CA4 P22748 1/20 0.35
CA6 P23280 1/20 0.35
CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7870212 0.93 EPHX1 (0.62) EPHX1CA2CA1CA7CA13
SCHEMBL28375139 0.91 EPHX1 (0.66) EPHX1CA2CA1CA7CNR1
SCHEMBL28379256 0.91 EPHX1 (0.66) EPHX1CA2CA1CA7CNR1
SCHEMBL6435794 0.86 EPHX1 (0.52) EPHX1CA2CA1CA7CA13
Hydrochloric Acid SCHEMBL927607 0.84 EPHX1 (0.50) EPHX1CA2CA1CA7CA13
SCHEMBL9951303 0.83 EPHX1 (0.47) EPHX1CA2CA1CNR1CNR2
SCHEMBL12789664 0.80 EPHX1 (0.60) EPHX1CA2CA1CA7CA13
SCHEMBL15904262 0.79 EPHX1 (0.61) EPHX1CA2CA1CA7CA13
SCHEMBL6435515 0.78 ALDH1A1 (0.56) CA2CA1MEN1KMT2AHTT
SCHEMBL6433489 0.77 CA2 (0.39) EPHX1CA2CA1CA7MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120077781-A1 FLAVIN DERIVATIVES GADWOOD ROBERT (US) 2012-03-29 US disclosed
US-20120077781-A1 FLAVIN DERIVATIVES GADWOOD ROBERT (US) 2012-03-29 US disclosed
US-20120077781-A1 FLAVIN DERIVATIVES GADWOOD ROBERT (US) 2012-03-29 US disclosed
EP-2320734-A1 FLAVIN DERIVATIVES BioRelix, Inc. (US) 2011-05-18 EP disclosed
WO-2010019208-A1 FLAVIN DERIVATIVES BIORELIX PHARMACEUTICALS, INC. (US) 2010-02-18 WO disclosed
WO-2010019208-A1 FLAVIN DERIVATIVES BIORELIX PHARMACEUTICALS, INC. (US) 2010-02-18 WO disclosed
US-6323174-B1 PERFUME COMPOSITION AT LEAST COMPRISING 4-METHYL-5-HEXEN-1-AL TAKASAGO INTERNATIONAL CORPORATION (JP) 2001-11-27 US disclosed
US-6239324-B1 REACTING A 1,3-BUTADIENE WITH OLEFIN IN PRESENCE OF HYDROPHILIC SOLVENT AND RUTHENIUM COMPOUND TAKASAGO INTERNATIONAL CORPORATION (JP) 2001-05-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120077781-A1 FLAVIN DERIVATIVES BLVRB, FLAD1, FDPS EPHX1 1247/4885CA2 4372/4885CA1 4881/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.