Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | USP5 | P45974 | 1/20 | 0.40 |
| ▸ | USP14 | P54578 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8644236 | 0.91 | SLC6A3 (0.49) | SLC6A3KDM1AGSK3BPDK2ALDH1A1 | |
| SCHEMBL8382436 | 0.83 | ITGB3 (0.47) | SLC6A3KDM1APDK2HRH3 | |
| SCHEMBL8642889 | 0.81 | HTT (0.41) | GRM5ALDH1A1SIGMAR1HRH3 | |
| SCHEMBL8643896 | 0.81 | SIGMAR1 (0.44) | SLC6A3GRM5GRM3KDM1AGSK3B | |
| SCHEMBL8650355 | 0.77 | KMT2A (0.51) | GRM5GSK3BSIGMAR1HRH3HRH1 | |
| SCHEMBL8379768 | 0.74 | GSK3B (0.54) | SLC6A3GSK3BALDH1A1TRPA1 | |
| SCHEMBL8379771 | 0.74 | GSK3B (0.54) | SLC6A3GSK3BALDH1A1TRPA1 | |
| SCHEMBL8645368 | 0.73 | ITGB3 (0.45) | ALDH1A1SIGMAR1HRH3 | |
| SCHEMBL8642886 | 0.72 | ITGB3 (0.41) | ALDH1A1SIGMAR1HRH3 | |
| SCHEMBL8643891 | 0.72 | SIGMAR1 (0.45) | SLC6A3KDM1AGSK3BPDK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726185-A | BINDING OF ADHESIVE PROTEINS TO BLOOD PLATELET AGGREGATION AND CELL TO CELL ADHESION | HOFFMANN-LA ROCHE INC. (US) | 1998-03-10 | — | — | US | disclosed |