Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 15/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8642468 | 0.81 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL8643067 | 0.79 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9596467 | 0.72 | ALDH1A1 (0.36) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL8195282 | 0.71 | OPRD1 (0.44) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9523959 | 0.71 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9524556 | 0.71 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9603010 | 0.70 | PDE4A (0.34) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9682834 | 0.70 | PDPK1 (0.39) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9088354 | 0.69 | ABCC9 (0.38) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9524863 | 0.69 | CLK4 (0.40) | PDE4APDE4BPDE4CPDE4DABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767787-B1 | (3,4-DIOXOCYCLOBUTEN-1-YL)CHROMENE, INDENE, AND DIHYDRONAPHTHALENONE DERIVATIVES AS SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PROD (US) | 1998-08-26 | — | — | EP | claimed |
| EP-0767787-A1 | (3,4-DIOXOCYCLOBUTEN-1-YL)CHROMENE, INDENE, AND DIHYDRONAPHTHALENONE DERIVATIVES AS SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-04-16 | — | — | EP | claimed |
| WO-1996000725-A1 | (3,4-DIOXOCYCLOBUTEN-1-YL)CHROMENE, INDENE, AND DIHYDRONAPHTHALENONE DERIVATIVES AS SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-11 | — | — | WO | claimed |
| US-5482942-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS AND MUSCULAR DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-09 | — | — | US | claimed |
| EP-0767787-B1 | (3,4-DIOXOCYCLOBUTEN-1-YL)CHROMENE, INDENE, AND DIHYDRONAPHTHALENONE DERIVATIVES AS SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PROD (US) | 1998-08-26 | — | — | EP | disclosed |
| EP-0767787-A1 | (3,4-DIOXOCYCLOBUTEN-1-YL)CHROMENE, INDENE, AND DIHYDRONAPHTHALENONE DERIVATIVES AS SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-04-16 | — | — | EP | disclosed |
| WO-1996000725-A1 | (3,4-DIOXOCYCLOBUTEN-1-YL)CHROMENE, INDENE, AND DIHYDRONAPHTHALENONE DERIVATIVES AS SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-11 | — | — | WO | disclosed |
| US-5482942-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS AND MUSCULAR DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-09 | — | — | US | disclosed |