Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 10/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | RARA | P10276 | 1/20 | 0.31 |
| ▸ | RARB | P10826 | 1/20 | 0.31 |
| ▸ | RARG | P13631 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.30 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | CTSD | P07339 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9596467 | 0.90 | ALDH1A1 (0.36) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9598102 | 0.88 | ABCC9 (0.36) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9682834 | 0.77 | PDPK1 (0.39) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL8642468 | 0.77 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9525564 | 0.70 | KDM1A (0.36) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL8643067 | 0.70 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL8645528 | 0.70 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9603012 | 0.70 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL8195282 | 0.70 | OPRD1 (0.44) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9527811 | 0.69 | ABCC9 (0.42) | PDE4APDE4BPDE4CPDE4DABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5189047-A | Useful in the treament of respiratory track disorder, hypertension and bronchodilator activity or utility as potassium channel activator | BEECHAM GROUP P.L.C. (GB) | 1993-02-23 | — | — | US | disclosed |