Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | CTSG | P08311 | 2/20 | 0.36 |
| ▸ | CMA1 | P23946 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8648540 | 0.83 | NPC1 (0.40) | MAPTSMN1; SMN2KDM4EALDH1A1MMP2 | |
| SCHEMBL8648543 | 0.80 | NPC1 (0.39) | MAPTKDM4EALDH1A1MMP2ANPEP | |
| SCHEMBL8644943 | 0.80 | AMPD2 (0.39) | TACR1TACR3 | |
| SCHEMBL8648264 | 0.79 | MAPT (0.33) | MAPTSMN1; SMN2KDM4EALDH1A1TACR1 | |
| SCHEMBL8647266 | 0.79 | KMT2A (0.37) | SMN1; SMN2KDM4EALDH1A1TACR1TACR3 | |
| SCHEMBL8644950 | 0.79 | AMPD2 (0.38) | MAPTTACR1TACR3 | |
| SCHEMBL8645856 | 0.79 | MAPT (0.40) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8647457 | 0.79 | LMNA (0.33) | MAPTSMN1; SMN2TACR1TACR3TP53 | |
| SCHEMBL8645908 | 0.78 | MAPT (0.35) | MAPTTACR1TACR3TP53 | |
| SCHEMBL8645861 | 0.78 | MAPT (0.44) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843972-A | Heterocyclic β-adrenergic agonists | PFIZER INC. (US) | 1998-12-01 | — | — | US | disclosed |
| EP-0801060-A1 | Heterocyclic Beta-3 Adrenergenic Agonists | PFIZER INC. (US) | 1997-10-15 | — | — | EP | disclosed |