SCHEMBL8645930

SCHEMBL8645930

O=C(O)c1nc2cccc(F)c2c(F)c1F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.50
MAPT P10636 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
DYRK1A Q13627 6/20 0.42
ALB P02768 1/20 0.42
PARP1 P09874 2/20 0.41
CES2 O00748 1/20 0.40
BCHE P06276 1/20 0.40
CES1 P23141 1/20 0.40
KDM4E B2RXH2 3/20 0.40
ASPH Q12797 1/20 0.40
KDM8 Q8N371 1/20 0.40
DYRK1B Q9Y463 4/20 0.39
DYRK2 Q92630 3/20 0.39
DYRK3 O43781 1/20 0.39
CLK1 P49759 2/20 0.38
CDK9 P50750 2/20 0.38
CLK4 Q9HAZ1 2/20 0.38
CDK5 Q00535 1/20 0.38
CLK2 P49760 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10880867 0.81 KDM4E (0.37) ALDH1A1MAPTSMN1; SMN2DYRK1AKDM4E
SCHEMBL8946304 0.77 ALDH1A1 (0.61) ALDH1A1MAPTSMN1; SMN2DYRK1AKDM4E
SCHEMBL7596408 0.75 ALDH1A1 (0.48) ALDH1A1MAPTSMN1; SMN2DYRK1AALB
SCHEMBL27695809 0.74 PARP1 (0.44) MAPTPARP1KDM4E
SCHEMBL16832509 0.73 KDM4E (0.45) ALDH1A1SMN1; SMN2ALBPARP1KDM4E
SCHEMBL28100578 0.73 TACR3 (0.44) ALDH1A1MAPTSMN1; SMN2DYRK1APARP1
SCHEMBL7850886 0.72 KMO (0.54) ALDH1A1MAPTSMN1; SMN2DYRK1APARP1
SCHEMBL9536708 0.71 ALDH1A1 (0.40) ALDH1A1MAPTSMN1; SMN2DYRK1AALB
SCHEMBL27656249 0.71 ALB (0.44) ALDH1A1MAPTSMN1; SMN2DYRK1AALB
SCHEMBL10581936 0.71 ACHE (0.46) ALDH1A1MAPTPARP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0126355-B1 7-AMINO-1-CYCLOPROPYL-6,8-DIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE-CARBOXYLIC ACID, PROCESSES FOR THEIR PREPARATION AND ANTIBACTERIAL AGENTS CONTAINING THEM BAYER AG (DE) 1987-09-09 EP claimed
EP-0126355-A1 7-Amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid, processes for their preparation and antibacterial agents containing them BAYER AG (DE) 1984-11-28 EP claimed
EP-0684942-B1 METHOD FOR PREPARING QUINOLINE CARBOXYLIC ACIDS AND DERIVATIVES THEREOF HOECHST CELANESE CORP (US) 1998-06-10 EP disclosed
EP-0684942-A4 1995-12-27 EP disclosed
EP-0684942-A1 METHOD FOR PREPARING QUINOLINE CARBOXYLIC ACIDS AND DERIVATIVES THEREOF HOECHST CELANESE CORPORATION (US) 1995-12-06 EP disclosed
US-5430152-A Heating aminoarylester in presence of chlorosulfonic acid, oleum HOECHST CELANESE CORPORATION (US) 1995-07-04 US disclosed
WO-1994019312-A1 METHOD FOR PREPARING QUINOLINE CARBOXYLIC ACIDS AND DERIVATIVES THEREOF HOECHST CELANESE CORPORATION (US) 1994-09-01 WO disclosed
US-4657913-A Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents WARNER-LAMBERT COMPANY (US) 1987-04-14 US disclosed