SCHEMBL8646458

SCHEMBL8646458

Cc1ccc(O)c(C(C)Cc2ccccc2)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 3/20 0.50
CHRM2 P08172 2/20 0.50
CHRM5 P08912 2/20 0.50
CHRM3 P20309 2/20 0.50
HRH1 P35367 2/20 0.50
LMNA P02545 2/20 0.50
ADRA1A P35348 2/20 0.50
SLC6A4 P31645 2/20 0.50
ESR1 P03372 1/20 0.50
CHRM4 P08173 1/20 0.50
MAPT P10636 1/20 0.50
KCNE1 P15382 1/20 0.50
PTGS1 P23219 1/20 0.50
HRH2 P25021 1/20 0.50
HTR2A P28223 1/20 0.50
OPRK1 P41145 1/20 0.50
KCNQ1 P51787 1/20 0.50
KCNH2 Q12809 1/20 0.50
CACNA1C Q13936 1/20 0.50
SCN5A Q14524 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9632210 0.91 LMNA (0.46) CHRM1CHRM2CHRM5CHRM3HRH1
SCHEMBL5163687 0.90 CHRM1 (0.43) CHRM1CHRM2CHRM5CHRM3HRH1
SCHEMBL7944724 0.85 CHRM1 (0.48) CHRM1CHRM2CHRM5CHRM3HRH1
SCHEMBL8749788 0.85 ESR1 (0.46) SLC6A4ESR1SIGMAR1ADRB2POLB
SCHEMBL16973200 0.83 ESR1 (0.49) SLC6A4ESR1SIGMAR1ADRB2POLB
SCHEMBL5699143 0.82 TRPA1 (0.47) CHRM1HRH1LMNAADRA1AESR1
SCHEMBL1868728 0.80 TSHR (0.64) SLC6A4SIGMAR1POLBMAPK1TAAR1
SCHEMBL4005281 0.80 CHRM2 (0.46) CHRM1CHRM2CHRM5CHRM3HRH1
SCHEMBL6546729 0.79 SIGMAR1 (0.44) SLC6A4SIGMAR1GAAKMT2ATAAR1
SCHEMBL6939529 0.78 RORC (0.59) CHRM1CHRM2CHRM5CHRM3HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101707914-B Resin composition TEIJIN LTD 2012-12-12 CN disclosed
CN-101707914-A Resin composition TEIJIN LTD 2010-05-12 CN disclosed
US-5811368-A BASIC LEUCO DYE, PHENOLIC COLOR DEVELOPER; IMPROVED STABILITY TO PLASTICIZERS NIPPON PAPER INDUSTRIES CO., LTD. (JP) 1998-09-22 US disclosed
US-5747414-A SUBSTRATE WITH COLOR LAYER, ALUMINUM HYDROXIDE AND A RESIN OF UREA-FORMALDEHYDE AND DEVELOPERS NIPPON PAPER INDUSTRIES, LTD. (JP) 1998-05-05 US disclosed
EP-0189760-B1 THERMOSENSITIVE RECORDING SHEET JUJO PAPER CO., LTD. (JP) 1989-07-19 EP disclosed
US-4721701-A Thermosensitive recording sheet JUJO PAPER CO., LTD. (JP) 1988-01-26 US disclosed
EP-0189760-A1 Thermosensitive recording sheet JUJO PAPER CO., LTD. (JP) 1986-08-06 EP disclosed
US-4463112-A STABILIZED COMPOSITIONS PHOENIX CHEMICAL CORPORATION, A CORP. OF DE. 1984-07-31 US disclosed