Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10305752 | 0.87 | MAPT (0.44) | MAPTSMN1; SMN2NPC1RAB9AALOX5 | |
| SCHEMBL31710727 | 0.83 | ALOX5 (0.44) | MAPTSMN1; SMN2NPC1RAB9AALOX5 | |
| SCHEMBL30313121 | 0.81 | GAA (0.43) | MAPTSMN1; SMN2NPC1RAB9AALOX5 | |
| SCHEMBL8664177 | 0.81 | MAPT (0.45) | MAPTSMN1; SMN2NPC1RAB9AALOX5 | |
| SCHEMBL28566645 | 0.80 | CACNA1H (0.46) | MAPTSMN1; SMN2NPC1RAB9AALOX5 | |
| SCHEMBL1019102 | 0.78 | MAPT (0.55) | MAPTSMN1; SMN2NPC1RAB9AALOX5 | |
| SCHEMBL372131 | 0.77 | PPARG (0.51) | MAPTALDH1A1L3MBTL1PPARGPPARA | |
| SCHEMBL19853209 | 0.75 | L3MBTL1 (0.51) | MAPTSMN1; SMN2NPC1RAB9AKDM4A | |
| SCHEMBL13055397 | 0.74 | KDM4A (0.51) | KDM4ATDP1L3MBTL1MEN1KMT2A | |
| SCHEMBL18664385 | 0.74 | HDAC1 (0.49) | ALDH1A1L3MBTL1PPARGPPARANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719152-A | Tricyclic quinoxalinedione derivatives | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 1998-02-17 | — | — | US | disclosed |
| EP-0627434-A1 | Tricyclic quinoxalinedione derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-12-07 | — | — | EP | disclosed |