SCHEMBL372131

SCHEMBL372131

CC(C)(C)OC(=O)NCc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.51
PPARA Q07869 1/20 0.51
L3MBTL1 Q9Y468 2/20 0.50
GAA P10253 2/20 0.50
CA2 P00918 2/20 0.48
NAMPT P43490 2/20 0.48
CA1 P00915 1/20 0.48
EPHX1 P07099 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
MMP1 P03956 1/20 0.47
MMP2 P08253 1/20 0.47
MMP9 P14780 1/20 0.47
MMP8 P22894 1/20 0.47
MMP13 P45452 1/20 0.47
ALDH1A1 P00352 2/20 0.47
MAPK1 P28482 1/20 0.47
APOBEC3A P31941 1/20 0.47
APOBEC3G Q9HC16 1/20 0.47
MAPT P10636 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18664385 0.96 HDAC1 (0.49) PPARGPPARAL3MBTL1GAACA2
SCHEMBL27262445 0.96 PPARG (0.48) PPARGPPARAL3MBTL1GAACA2
Methyl Alcohol SCHEMBL12492352 0.92 PPARG (0.46) PPARGPPARAL3MBTL1GAACA2
SCHEMBL29510988 0.92 PPARD (0.48) PPARGPPARAL3MBTL1GAACA2
SCHEMBL13456452 0.91 CA2 (0.49) PPARGPPARAL3MBTL1GAACA2
SCHEMBL26185842 0.90 MAOB (0.58) GAACA2CA1CYP2C9CYP2C19
SCHEMBL29460423 0.87 MMP1 (0.51) L3MBTL1GAANAMPTCYP2C9CYP2C19
SCHEMBL1717941 0.86 MAPT (0.56) PPARGPPARACA2NAMPTCA1
SCHEMBL3558360 0.86 PPARG (0.49) PPARGPPARAGAAMMP1MMP2
SCHEMBL3180689 0.86 L3MBTL1 (0.61) L3MBTL1GAACA2NAMPTCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 233 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250214963-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH PFIZER INC. 2025-07-03 US disclosed
US-20240109862-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH PFIZER INC. 2024-04-04 US disclosed
US-20220251066-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH PFIZER INC. 2022-08-11 US disclosed
CN-109153648-B Benzazepine dicarboxamide compounds having tertiary amide functional group 豪夫迈·罗氏有限公司 2022-07-22 CN disclosed
EP-3329918-B1 C-MET MODULATORS AND METHODS OF USE EXELIXIS INC (US) 2022-05-25 EP disclosed
US-11124482-B2 C-met modulators and methods of use EXELIXIS, INC. (US) 2021-09-21 US disclosed
US-20210253530-A9 C-MET MODULATORS AND METHODS OF USE EXELIXIS, INC. 2021-08-19 US disclosed
CN-106349233-B 3, 4-diphenyl-4H-1, 2, 4-triazole derivative and preparation method and application thereof 上海翰森生物医药科技有限公司 2021-06-01 CN disclosed
US-20200331860-A1 C-Met Modulators and Methods of Use EXELIXIS INC (US) 2020-10-22 US disclosed
EP-3464245-B1 BENZAZEPINE DICARBOXAMIDE COMPOUNDS WITH TERTIARY AMIDE FUNCTION HOFFMANN LA ROCHE (CH) 2020-10-14 EP disclosed
US-5693636-A Bicyclic fibrinogen antagonists SMITHKLINE BEECHAM CORPORATION (US) 1997-12-02 US disclosed
EP-0799191-A1 ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE THE WELLCOME FOUNDATION LIMITED (GB) 1997-10-08 EP disclosed
US-5563141-A INHIBIT CELL ADHESION FOR EXAMPLE, PLATELET AGGRE GATION ZENECA LIMITED (GB) 1996-10-08 US disclosed
WO-1996019440-A1 ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE THE WELLCOME FOUNDATION LIMITED (GB) 1996-06-27 WO disclosed
WO-1996002510-A1 NOVEL 1-[4(AMINO METHYL)PHENYL] SUBSTITUTED QUINOLONE CARBOXYLIC ACIDS BAYER AKTIENGESELLSCHAFT (DE) 1996-02-01 WO disclosed
WO-1996002511-A1 NOVEL N1 DIVERSE 6-FLUORINE-8-DIFLUOROMETHOXY SUBSTITUTED QUINOLONE CARBOXYLIC ACIDS BAYER AKTIENGESELLSCHAFT (DE) 1996-02-01 WO disclosed
EP-0690847-A1 HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS ZENECA LIMITED (GB) 1996-01-10 EP disclosed
WO-1994022835-A2 HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS ZENECA LIMITED (GB) 1994-10-13 WO disclosed
US-4548904-A FORMING REACTION PRODUCT OF PROTEIN AND REAGENT, DEGRADATION TO REMOVE TERMINAL AMINO ACID, THEN CHROMATOGRAPHY ANALYSIS MOLECULAR GENETICS RESEARCH & DEVELOPMENT (US) 1985-10-22 US disclosed
EP-0113538-A2 Protein sequencing method and reagent MOLECULAR GENETICS RESEARCH & DEVELOPMENT LIMITED PARTNERSHIP (US) 1984-07-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200331860-A1 C-Met Modulators and Methods of Use FLT4, FLT1, MET PPARG 2948/4885PPARA 3721/4885L3MBTL1 2294/4885
US-20250214963-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH GPR119, INSR, LYAR PPARG 726/4885PPARA 641/4885L3MBTL1 616/4885
US-20210253530-A9 C-MET MODULATORS AND METHODS OF USE FLT4, FLT1, MET PPARG 2948/4885PPARA 3721/4885L3MBTL1 2294/4885
US-20240109862-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH GPR119, INSR, LYAR PPARG 726/4885PPARA 641/4885L3MBTL1 616/4885
US-11124482-B2 C-met modulators and methods of use FLT4, FLT1, MET PPARG 2948/4885PPARA 3721/4885L3MBTL1 2294/4885
US-20220251066-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH GPR119, INSR, LYAR PPARG 726/4885PPARA 641/4885L3MBTL1 616/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.