Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 6/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28511791 | 0.94 | ALOX12 (0.53) | ALOX12TDP1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL3043213 | 0.86 | ALOX12 (0.47) | ALOX12ALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL22193741 | 0.82 | ALOX12 (0.49) | ALOX12TDP1SMN1; SMN2HPGDLMNA | |
| SCHEMBL11289350 | 0.80 | ALOX12 (0.51) | ALOX12TDP1TSHRTBXA2RTBXAS1 | |
| SCHEMBL25499775 | 0.78 | ALOX12 (0.45) | ALOX12TDP1ALDH1A1SMN1; SMN2LMNA | |
| Octanedioate SCHEMBL7080168 | 0.78 | TSHR (0.55) | TDP1ALDH1A1LMNATSHRNFKB1 | |
| SCHEMBL290460 | 0.78 | LMNA (0.41) | SMN1; SMN2LMNATSHRNFKB1PMP22 | |
| SCHEMBL25408775 | 0.76 | TSHR (0.43) | TDP1ALDH1A1SMN1; SMN2LMNATSHR | |
| SCHEMBL25408793 | 0.76 | TSHR (0.43) | TDP1ALDH1A1SMN1; SMN2LMNATSHR | |
| SCHEMBL25408300 | 0.76 | TSHR (0.43) | TDP1ALDH1A1SMN1; SMN2LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807688-A | ANTIBODY DIRECTED ANZYME PRODRUG THERAPY | ZENECA LIMITED (GB) | 1998-09-15 | — | — | US | disclosed |
| EP-0745673-A2 | Catalytic antibody regulated prodrug therapy | ZENECA LIMITED (GB) | 1996-12-04 | — | — | EP | disclosed |