SCHEMBL8653188

SCHEMBL8653188

Oc1cccc(C=Cc2nc(C(Cl)(Cl)Cl)nc(C(Cl)(Cl)Cl)n2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LCK P06239 2/20 0.51
CYSLTR2 Q9NS75 1/20 0.46
CYSLTR1 Q9Y271 1/20 0.46
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
NPC1 O15118 1/20 0.44
ABL1 P00519 1/20 0.44
BCR P11274 1/20 0.44
CCNB2 O95067 1/20 0.44
CDK1 P06493 1/20 0.44
CDK4 P11802 1/20 0.44
CCNB1 P14635 1/20 0.44
CCND1 P24385 1/20 0.44
CCNB3 Q8WWL7 1/20 0.44
FBP1 P09467 1/20 0.41
KDM1A O60341 1/20 0.40
PTGS2 P35354 2/20 0.39
PTGS1 P23219 1/20 0.39
MAOA P21397 2/20 0.39
MMP1 P03956 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20450511 0.81 RELA (0.54) MEN1KMT2ANPC1ABL1BCR
SCHEMBL1130906 0.81 RELA (0.54) MEN1KMT2ANPC1ABL1BCR
SCHEMBL2879274 0.80 APP (0.42) LCKMEN1KMT2ANPC1ABL1
SCHEMBL8652709 0.80 APP (0.42) LCKMEN1KMT2ANPC1ABL1
SCHEMBL79977 0.80 PDE5A (0.42) MEN1KMT2ANPC1ADORA3MAOB
SCHEMBL26432676 0.80 PDE5A (0.42) MEN1KMT2ANPC1ADORA3MAOB
SCHEMBL79976 0.80 PDE5A (0.42) MEN1KMT2ANPC1ADORA3MAOB
SCHEMBL6838983 0.78 CYSLTR2 (0.40) LCKCYSLTR2CYSLTR1MAOAMAOB
SCHEMBL6838982 0.78 CYSLTR2 (0.40) LCKCYSLTR2CYSLTR1MAOAMAOB
SCHEMBL1130384 0.78 TUBB4A (0.49) MEN1KMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5763122-A Low optical dot gain color proof composites IMATION CORP. (US) 1998-06-09 US disclosed
EP-0585164-B1 Use of alkali soluble photopolymer in color proofing constructions MINNESOTA MINING & MFG (US) 1997-10-29 EP disclosed
US-5374501-A Negative proofing film construction comprising a flexible support and a colorant layer containing a nucleophilically substituted anionic poly-2-vinylazlactone; non-tacky; oxidation resistance; shelf life MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-12-20 US disclosed
EP-0585164-A1 Use of alkali soluble photopolymer in color proofing constructions MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-03-02 EP disclosed