Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.48 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28334704 | 0.82 | KDM4E (0.68) | KDM4EHTTKMT2AMEN1HSD11B1 | |
| SCHEMBL13873443 | 0.81 | HTT (0.66) | KDM4EHTTKMT2AMEN1HSD11B1 | |
| SCHEMBL8879807 | 0.79 | KDM4E (1.00) | KDM4EHTTKMT2AMEN1HSD11B1 | |
| SCHEMBL17702625 | 0.78 | KMT2A (0.70) | KDM4EHTTKMT2AMEN1HSD11B1 | |
| SCHEMBL27004615 | 0.78 | HTT (0.62) | KDM4EHTTKMT2AMEN1HSD11B1 | |
| SCHEMBL16064965 | 0.77 | HTT (0.60) | KDM4EHTTKMT2AMEN1HSD11B1 | |
| SCHEMBL17703564 | 0.77 | KDM4E (0.60) | KDM4EHTTKMT2AMEN1HSD11B1 | |
| SCHEMBL6891227 | 0.77 | ALDH1A1 (0.62) | KDM4EHTTKMT2AMEN1EPHX2 | |
| SCHEMBL7702205 | 0.76 | ALDH1A1 (0.59) | KDM4EHTTKMT2AMEN1HSD11B1 | |
| SCHEMBL1193166 | 0.75 | KDM4E (0.58) | KDM4EHTTKMT2AMEN1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834493-A | TREATMENT OF NERVOUS SYSTEM DISORDERS | GIL QUINTERO MYRNA (IT) | 1998-11-10 | — | — | US | disclosed |
| EP-0694033-A1 | INDOLE DERIVATIVES AS 5-HT1A AND/OR 5-HT2 LIGANDS | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1996-01-31 | — | — | EP | disclosed |
| WO-1994024125-A1 | INDOLE DERIVATIVES AS 5-HT1A AND/OR 5-HT2 LIGANDS | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1994-10-27 | — | — | WO | disclosed |