Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.50 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.50 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16365921 | 0.86 | KDM4E (0.76) | KDM4EHTTKMT2AMEN1HPGD | |
| SCHEMBL1758666 | 0.81 | HTT (0.68) | KDM4EHTTKMT2AMEN1HPGD | |
| SCHEMBL28334704 | 0.81 | KDM4E (0.68) | KDM4EHTTKMT2AMEN1HPGD | |
| SCHEMBL8655345 | 0.79 | KDM4E (0.66) | KDM4EHTTKMT2AMEN1HPGD | |
| SCHEMBL13873443 | 0.79 | HTT (0.66) | KDM4EHTTKMT2AMEN1HPGD | |
| SCHEMBL7778418 | 0.78 | KDM4E (0.64) | KDM4EHTTKMT2AMEN1HPGD | |
| SCHEMBL20999491 | 0.77 | KDM4E (0.63) | KDM4EHTTKMT2AMEN1HPGD | |
| SCHEMBL27004615 | 0.76 | HTT (0.62) | KDM4EHTTKMT2AMEN1HPGD | |
| SCHEMBL17702625 | 0.76 | KMT2A (0.70) | KDM4EHTTKMT2AMEN1HPGD | |
| SCHEMBL22005490 | 0.76 | KDM4E (0.60) | KDM4EHTTKMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679701-A | INHIBITS CALCIUM UPTAKE IN CARDIAC MUSCLE; HAS NEGATIVE INOTROPIC EFFECT ON MAMMALIAN CARDIAC MUSCLE | INDIANA UNIVERSITY FOUNDATION (US) | 1997-10-21 | — | — | US | disclosed |
| US-5510500-A | RADIO-IODINATED ALANINE DERIVATIVES AS LABELS | INDIANA UNIVERSITY FOUNDATION (US) | 1996-04-23 | — | — | US | disclosed |
| US-5432288-A | Useful in effecting calcium efflux in tissue | INDIANA UNIVERSITY FOUNDATION (US) | 1995-07-11 | — | — | US | disclosed |
| WO-1992018499-A1 | NOVEL ESTER DERIVATIVES OF RYANODINE AND DEHYDRORYANODINE | INDIANA UNIVERSITY FOUNDATION (US) | 1992-10-29 | — | — | WO | disclosed |