Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.74 |
| ▸ | RAB9A | P51151 | 3/20 | 0.74 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | S100B | P04271 | 1/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19970692 | 1.00 | NPC1 (0.74) | NPC1RAB9ANLRP3L3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL29536468 | 0.88 | NPC1 (0.85) | NPC1RAB9ANLRP3L3MBTL1MEN1 | |
| SCHEMBL19970699 | 0.88 | NPC1 (0.85) | NPC1RAB9ANLRP3L3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL866737 | 0.87 | APAF1 (0.57) | NPC1RAB9ANLRP3L3MBTL1MEN1 | |
| SCHEMBL20555119 | 0.87 | APAF1 (0.57) | NPC1RAB9ANLRP3L3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL930666 | 0.85 | L3MBTL1 (1.00) | NPC1RAB9ANLRP3L3MBTL1MEN1 | |
| SCHEMBL3130463 | 0.85 | L3MBTL1 (1.00) | NPC1RAB9ANLRP3L3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL28418789 | 0.84 | NPC1 (0.79) | NPC1RAB9ANLRP3L3MBTL1MEN1 | |
| Butane SCHEMBL931598 | 0.84 | NPC1 (0.49) | NPC1RAB9ANLRP3L3MBTL1MEN1 | |
| SCHEMBL31680480 | 0.83 | NPC1 (0.47) | NPC1RAB9ANLRP3L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619244-B1 | IMPROVED METHOD OF PRODUCING POLYMERIC PHENAZONIUM COMPOUNDS | MACDERMID ACUMEN INC (US) | 2018-11-14 | — | — | EP | claimed |
| US-20140163198-A1 | Method of Producing Polymeric Phenazonium Compounds | MACDERMID ACUMEN, INC. (US) | 2014-06-12 | — | — | US | claimed |
| US-8735580-B2 | Method of producing polymeric phenazonium compounds | CITIBANK, N.A. | 2014-05-27 | — | — | US | claimed |
| EP-2619244-A1 | IMPROVED METHOD OF PRODUCING POLYMERIC PHENAZONIUM COMPOUNDS | MacDermid Acumen, Inc. (US) | 2013-07-31 | — | — | EP | claimed |
| US-20120073981-A1 | Method of Producing Polymeric Phenazonium Compounds | CITIBANK, N.A. | 2012-03-29 | — | — | US | claimed |
| WO-2012040417-A1 | IMPROVED METHOD OF PRODUCING POLYMERIC PHENAZONIUM COMPOUNDS | MACDERMID ACUMEN, INC. (US) | 2012-03-29 | — | — | WO | claimed |
| US-20120077956-A1 | Method of Producing Polymeric Phenazonium Compounds | CITIBANK, N.A. | 2012-03-29 | — | — | US | claimed |
| EP-2619244-B1 | IMPROVED METHOD OF PRODUCING POLYMERIC PHENAZONIUM COMPOUNDS | MACDERMID ACUMEN INC (US) | 2018-11-14 | — | — | EP | disclosed |
| US-9040700-B2 | Method of producing polymeric phenazonium compounds | CITIBANK, N.A. | 2015-05-26 | — | — | US | disclosed |
| US-20140163198-A1 | Method of Producing Polymeric Phenazonium Compounds | MACDERMID ACUMEN, INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-8735580-B2 | Method of producing polymeric phenazonium compounds | CITIBANK, N.A. | 2014-05-27 | — | — | US | disclosed |
| EP-2619244-A1 | IMPROVED METHOD OF PRODUCING POLYMERIC PHENAZONIUM COMPOUNDS | MacDermid Acumen, Inc. (US) | 2013-07-31 | — | — | EP | disclosed |
| US-20120073981-A1 | Method of Producing Polymeric Phenazonium Compounds | CITIBANK, N.A. | 2012-03-29 | — | — | US | disclosed |
| WO-2012040417-A1 | IMPROVED METHOD OF PRODUCING POLYMERIC PHENAZONIUM COMPOUNDS | MACDERMID ACUMEN, INC. (US) | 2012-03-29 | — | — | WO | disclosed |
| US-20120077956-A1 | Method of Producing Polymeric Phenazonium Compounds | CITIBANK, N.A. | 2012-03-29 | — | — | US | disclosed |
| US-4118384-A | DIAZOTIZATION | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120073981-A1 | Method of Producing Polymeric Phenazonium Compounds | NOX5, PRMT5, CHRM5 | ACHE 396/4885NPC1 4874/4885RAB9A 1380/4885 |
| US-20140163198-A1 | Method of Producing Polymeric Phenazonium Compounds | NOX5, PRMT5, H1-5 | ACHE 590/4885NPC1 4882/4885RAB9A 1573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.