Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13855694 | 0.86 | GFER (0.44) | MAPTRAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL8656943 | 0.86 | LMNA (0.47) | MAPTRAB9ASMN1; SMN2POLBKDM4E | |
| SCHEMBL8654289 | 0.85 | LMNA (0.46) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8643569 | 0.84 | CTSL (0.39) | ALDH1A1TSHRUSP2HSD17B10 | |
| SCHEMBL8656349 | 0.84 | MAOA (0.47) | MAPTKMT2AALDH1A1 | |
| SCHEMBL8655270 | 0.84 | ALDH1A1 (0.48) | MAPTSMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL8657602 | 0.84 | AKR1C3 (0.42) | MAPTMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL8656553 | 0.82 | HTR2A (0.47) | MAPTALDH1A1TSHRHTT | |
| SCHEMBL8642619 | 0.81 | ALDH1A1 (0.38) | MAPTSMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL8654828 | 0.81 | ALDH1A1 (0.38) | MAPTSMN1; SMN2MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858453-A1 | 5-(ACETAMIDOMETHYL)-3-ARYLDIHYDROFURAN-2-ONE AND TETRAHYDROFURAN-2-ONE DERIVATIVES WITH ANTIBIOTIC ACTIVITY | AstraZeneca AB (SE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997014690-A1 | 5-(ACETAMIDOMETHYL)-3-ARYLDIHYDROFURAN-2-ONE AND TETRAHYDROFURAN-2-ONE DERIVATIVES WITH ANTIBIOTIC ACTIVITY | ZENECA LIMITED (GB) | 1997-04-24 | — | — | WO | disclosed |