Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB1 | P11230 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 12/20 | 0.44 |
| ▸ | HTR2A | P28223 | 10/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 7/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | ATR | Q13535 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8620775 | 0.89 | HTR2C (0.45) | HTR2CHTR2AHTR1AHTR1DHTR1B | |
| SCHEMBL8618277 | 0.89 | HTR1A (0.47) | HTR2CHTR2AHTR1AHTR1DHTR1B | |
| SCHEMBL8617192 | 0.83 | HTR1A (0.49) | HTR2CHTR2AHTR1AHTR1DHTR1B | |
| SCHEMBL8618434 | 0.83 | HTR1A (0.46) | HTR2CHTR2AHTR1AHTR1DHTR1B | |
| SCHEMBL8119472 | 0.78 | HTR1A (0.64) | HTR2CHTR2AHTR1AHTR1DHTR1B | |
| SCHEMBL8623325 | 0.76 | HTR2C (0.51) | HTR2CHTR2AHTR1AHTR1DHTR1B | |
| SCHEMBL8616709 | 0.74 | HTR2C (0.49) | HTR2CHTR2AHTR1AHTR1DHTR1B | |
| SCHEMBL8137640 | 0.73 | HTR1A (0.63) | HTR2CHTR2AHTR1AHTR1DHTR1B | |
| SCHEMBL8658481 | 0.70 | HTR1A (0.55) | HTR2CHTR2AHTR1AHTR1DHTR1B | |
| SCHEMBL8139246 | 0.70 | HTR1A (0.61) | HTR2CHTR2AHTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |