Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8656925 | 0.81 | PKM (0.63) | PKMESR1CA12CA9ALDH1A1 | |
| SCHEMBL812682 | 0.80 | PKM (0.79) | PKMHTR6ESR1CA12CA9 | |
| SCHEMBL8659118 | 0.80 | PKM (0.53) | PKMHTR6ESR1CA12CA9 | |
| SCHEMBL8663371 | 0.80 | PKM (0.53) | PKMHTR6ESR1CA12CA9 | |
| SCHEMBL8659634 | 0.79 | PKM (0.51) | PKMHTR6ESR1CA12CA9 | |
| SCHEMBL8658024 | 0.79 | PKM (0.51) | PKMHTR6ESR1CA12CA9 | |
| SCHEMBL3258764 | 0.79 | ESR1 (0.61) | PKMESR1CA12CA9ALDH1A1 | |
| SCHEMBL8658317 | 0.79 | PKM (0.59) | PKMESR1CA12CA9ALDH1A1 | |
| SCHEMBL25406065 | 0.78 | PKM (0.50) | PKMHTR6ESR1CA12CA9 | |
| SCHEMBL8659474 | 0.78 | PKM (0.50) | PKMHTR6ESR1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |