SCHEMBL8662865

SCHEMBL8662865

[O-][S+](c1cc(C(F)(F)F)[nH]c1-c1ccc(Cl)cc1)C(F)(F)F

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 2/20 0.33
MEN1 O00255 1/20 0.33
LMNA P02545 1/20 0.33
GLA P06280 1/20 0.33
GAA P10253 1/20 0.33
HPGD P15428 1/20 0.33
CRHBP P24387 1/20 0.33
HTT P42858 1/20 0.33
KMT2A Q03164 1/20 0.33
CRHR2 Q13324 1/20 0.33
GCGR P47871 3/20 0.32
MAPK14 Q16539 2/20 0.31
HSD17B10 Q99714 1/20 0.31
TNF P01375 1/20 0.31
NOD1 Q9Y239 1/20 0.31
PTGS1 P23219 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7784932 0.84 KDM4E (0.32) MAPTNPSR1L3MBTL1KDM4EALDH1A1
SCHEMBL7782874 0.80 MAPK14 (0.34) MAPTKDM4EALDH1A1MEN1HPGD
SCHEMBL7782948 0.77 NISCH (0.32) MAPTNPSR1L3MBTL1GCGRMAPK14
SCHEMBL8798565 0.74 KDM4E (0.43) MAPTNPSR1L3MBTL1KDM4EALDH1A1
SCHEMBL9015117 0.74 GCGR (0.50) MAPTNPSR1L3MBTL1KDM4EALDH1A1
SCHEMBL29172448 0.72 GCGR (0.38) MAPTNPSR1L3MBTL1KDM4EALDH1A1
SCHEMBL8662416 0.72 GCGR (0.33) MAPTNPSR1L3MBTL1GCGRMAPK14
SCHEMBL9161145 0.71 SLC6A2 (0.34) LMNA
SCHEMBL8663240 0.70 PTGS2 (0.31) MAPTNPSR1L3MBTL1GCGRMAPK14
SCHEMBL8664038 0.69 KDM4E (0.34) MAPTNPSR1L3MBTL1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5739155-A Haloalkylthio,-sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents AMERICAN CYANAMID CO. (US) 1998-04-14 US disclosed
EP-0549866-B1 Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal, acaricidal and fungicidal agents AMERICAN CYANAMID CO (US) 1997-08-13 EP disclosed
US-5484807-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents BASF AKTIENGESELLSCHAFT 1996-01-16 US disclosed
US-5468877-A FOR PROTECTING CROPS AMERICAN CYANAMID COMPANY (US) 1995-11-21 US disclosed
US-5306827-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents AMERICAN CYANAMID COMPANY (US) 1994-04-26 US disclosed
US-5284863-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole fungicidal agents AMERICAN CYANAMID COMPANY (US) 1994-02-08 US disclosed
EP-0549866-A1 Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal, acaricidal and fungicidal agents AMERICAN CYANAMID COMPANY (US) 1993-07-07 EP disclosed