Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAT1 | P18440 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8657558 | 0.89 | ERBB2 (0.47) | NAT1ERBB2HSP90AA1HSP90AB1MEN1 | |
| SCHEMBL8658156 | 0.88 | NPSR1 (0.50) | MEN1KMT2AKAT6AFFAR4CYTH2 | |
| SCHEMBL8661445 | 0.87 | CA12 (0.51) | MEN1KMT2AALDH1A1LMNAPOLB | |
| SCHEMBL8660105 | 0.87 | PTGS2 (0.47) | ERBB2HSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL8656118 | 0.85 | PGR (0.52) | NAT1KDM1AERBB2HSP90AA1HSP90AB1 | |
| SCHEMBL8657424 | 0.85 | KMO (0.51) | MEN1KMT2AALDH1A1KAT6AFFAR4 | |
| SCHEMBL8661400 | 0.84 | STAT3 (0.48) | KAT6AFFAR4CYTH2 | |
| SCHEMBL8661364 | 0.84 | KAT6A (0.49) | ERBB2HSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL8659781 | 0.84 | KEAP1 (0.50) | ALDH1A1LMNAFFAR4CYTH2PGAM1 | |
| SCHEMBL8658238 | 0.84 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1KAT6AFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |