Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | CRHBP | P24387 | 2/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8421520 | 0.92 | KCNH2 (0.59) | KCNH2CRHBPCRHR2CYP2C19LMNA | |
| SCHEMBL17029337 | 0.90 | ALDH1A1 (0.57) | KCNH2CRHBPCRHR2CYP2C19LMNA | |
| SCHEMBL9344808 | 0.80 | CA1 (0.64) | KCNH2ALDH1A1 | |
| SCHEMBL463691 | 0.80 | KCNH2 (0.49) | KCNH2KDM4EHRH3SMN1; SMN2 | |
| SCHEMBL7367941 | 0.79 | KCNH2 (0.51) | KCNH2CRHBPCRHR2CYP2C19LMNA | |
| SCHEMBL17713993 | 0.79 | ALDH1A1 (0.52) | KCNH2CRHBPCRHR2CYP2C19LMNA | |
| SCHEMBL7564337 | 0.79 | TDP1 (0.58) | CYP2C19LMNATSHRTDP1KDM4E | |
| SCHEMBL15864626 | 0.78 | CYP1A2 (0.44) | KCNH2CRHBPCRHR2LMNATSHR | |
| SCHEMBL3152617 | 0.78 | PYCR1 (0.59) | KCNH2CRHBPCRHR2CYP2C19LMNA | |
| SCHEMBL15392240 | 0.78 | LOXL2 (0.59) | KCNH2CRHBPCRHR2CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0570574-B1 | BICYCLOPOLYAZAMACROCYCLOPHOSPHONIC ACID COMPLEXES, THEIR PREPARATION, CONJUGATES AND RADIOPHARMACEUTICALS | DOW CHEMICAL CO (US) | 1998-12-09 | — | — | EP | disclosed |
| US-5714631-A | FOR DELIVERING THERAPEUTIC RADIATION DOSES TO CALCIFIC TUMORS AND METASTATIC BONE CANCER | THE DOW CHEMICAL COMPANY (US) | 1998-02-03 | — | — | US | disclosed |
| US-5696239-A | BINDING TO ANTIBODIES; DIAGNOSIS, THERAPY TUMORS; RELIEF OFBONE PAIN | THE DOW CHEMICAL COMPANY (US) | 1997-12-09 | — | — | US | disclosed |
| US-5652361-A | ANTITUMOR | THE DOW CHEMICAL COMPANY (US) | 1997-07-29 | — | — | US | disclosed |
| EP-0566166-B1 | Chelants possessing ortho ligating functionality and complexes thereof | DOW CHEMICAL CO (US) | 1996-09-25 | — | — | EP | disclosed |
| EP-0570022-B1 | Chelants possessing ortho ligating functionality and complexes thereof | DOW CHEMICAL CO (US) | 1996-07-31 | — | — | EP | disclosed |
| US-5435990-A | Chelate-antibody complexes, treatment and diagnosis of cancer, tetraazacyclododecane compounds | THE DOW CHEMICAL COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| US-5428139-A | Anticarcinogenic agents | THE DOW CHEMICAL COMPANY (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0367223-B1 | Chelants possessing ortho ligating functionality and complexes thereof | DOW CHEMICAL CO (US) | 1995-04-26 | — | — | EP | disclosed |
| EP-0353450-B1 | Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates | DOW CHEMICAL CO (US) | 1995-03-29 | — | — | EP | disclosed |
| EP-0575583-A4 | BICYCLOPOLYAZAMACROCYCLOCARBOXYLIC ACID COMPLEXES, THEIR CONJUGATES PROCESSES FOR THEIR PREPARATION, AND USE AS RADIOPHARMACEUTICALS. | DOW CHEMICAL CO (US) | 1995-02-15 | — | — | EP | disclosed |
| WO-1994026315-A1 | BICYCLOPOLYAZAMACROCYCLOCARBOXYLIC ACID COMPLEXES, THEIR CONJUGATES, PROCESSES FOR THEIR PREPARATION, AND USE AS RADIOPHARMACEUTICALS | THE DOW CHEMICAL COMPANY (US) | 1994-11-24 | — | — | WO | disclosed |
| US-5342604-A | Bone disorders | THE DOW CHEMICAL COMPANY (US) | 1994-08-30 | — | — | US | disclosed |
| EP-0575583-A1 | BICYCLOPOLYAZAMACROCYCLOCARBOXYLIC ACID COMPLEXES, THEIR CONJUGATES PROCESSES FOR THEIR PREPARATION, AND USE AS RADIOPHARMACEUTICALS | THE DOW CHEMICAL COMPANY (US) | 1993-12-29 | — | — | EP | disclosed |
| EP-0570022-A2 | Chelants possessing ortho ligating functionality and complexes thereof | THE DOW CHEMICAL COMPANY (US) | 1993-11-18 | — | — | EP | disclosed |
| EP-0566166-A1 | Chelants possessing ortho ligating functionality and complexes thereof | THE DOW CHEMICAL COMPANY (a Delaware corporation) (US) | 1993-10-20 | — | — | EP | disclosed |
| WO-1993012112-A1 | BICYCLOPOLYAZAMACROCYCLOCARBOXYLIC ACID COMPLEXES, THEIR CONJUGATES PROCESSES FOR THEIR PREPARATION, AND USE AS RADIOPHARMACEUTICALS | THE DOW CHEMICAL COMPANY (US) | 1993-06-24 | — | — | WO | disclosed |
| EP-0420942-A1 | MACROCYCLIC BIFUNCTIONAL CHELANTS, COMPLEXES THEREOF AND THEIR ANTIBODY CONJUGATES | THE DOW CHEMICAL COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |
| WO-1989012631-A1 | MACROCYCLIC BIFUNCTIONAL CHELANTS, COMPLEXES THEREOF AND THEIR ANTIBODY CONJUGATES | THE DOW CHEMICAL COMPANY (US) | 1989-12-28 | — | — | WO | disclosed |