Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 12/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31542127 | 1.00 | TRPV4 (0.42) | TRPV4ARCYP11B2HTR2AHTR2C | |
| SCHEMBL10944659 | 0.86 | AR (0.43) | TRPV4ARCYP11B2HTR2AHTR2C | |
| SCHEMBL9845641 | 0.84 | TRPV4 (0.43) | TRPV4ARCYP11B2VCAM1CYP11B1 | |
| SCHEMBL3333071 | 0.82 | CYP11B2 (0.42) | TRPV4ARCYP11B2HTR2AHTR2C | |
| SCHEMBL29774747 | 0.82 | TRPV4 (0.42) | TRPV4ARCYP11B2HTR2AHTR2C | |
| SCHEMBL8859185 | 0.82 | TRPV4 (0.42) | TRPV4ARCYP11B2HTR2AHTR2C | |
| SCHEMBL29774748 | 0.80 | TRPV4 (0.41) | TRPV4ARCYP11B2HTR2AHTR2C | |
| SCHEMBL25304895 | 0.78 | TRPV4 (0.39) | TRPV4ARCYP11B2VCAM1CYP11B1 | |
| SCHEMBL15594078 | 0.78 | AR (0.41) | TRPV4ARCYP11B2 | |
| SCHEMBL13199474 | 0.78 | AR (0.45) | ARHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110372538-A | The synthetic method of one kind 2,6- dichloro-3-fluorobenzonitrile | 浙江林江化工股份有限公司 | 2019-10-25 | — | — | CN | claimed |
| CN-102531961-B | Preparation method of 2,6-dichloro-3-fluorobenzonitrile | UNIV ZHEJIANG TECHNOLOGY | 2014-06-11 | — | — | CN | claimed |
| EP-0635486-B1 | Process for the preparation of fluorobenzonitriles | CLARIANT GMBH (DE) | 1998-12-09 | — | — | EP | claimed |
| US-5466859-A | Process for preparing fluorobenzonitriles | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-11-14 | — | — | US | claimed |
| EP-0635486-A2 | Process for the preparation of fluorobenzonitriles | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-01-25 | — | — | EP | claimed |
| US-20220306630-A1 | AGONISTS OF ROR GAMMAt | BRISTOL MYERS SQUIBB CO (US) | 2022-09-29 | — | — | US | disclosed |
| EP-3774774-B1 | PYRIDINE SUBSTITUTED 2,2'-DI-9H-CARBAZOL-9-YL-[1,1'-BIPHENYL]-DICARBONITRILE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN OPTOELECTRONIC DEVICES | CYNORA GMBH (DE) | 2022-07-13 | — | — | EP | disclosed |
| EP-3774774-A1 | PYRIDINE-SUBSTITUTED 2,2'-DI-9H-CARBAZOL-9-YL-[1,1'-BIPHENYL]DICARBONITRILE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN OPTOELECTRONIC APPARATUSES | cynora GmbH (DE) | 2021-02-17 | — | — | EP | disclosed |
| WO-2021026179-A1 | AGONISTS OF ROR GAMMAt | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-02-11 | — | — | WO | disclosed |
| WO-2021026179-A1 | AGONISTS OF ROR GAMMAt | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-02-11 | — | — | WO | disclosed |
| CN-110372538-A | The synthetic method of one kind 2,6- dichloro-3-fluorobenzonitrile | 浙江林江化工股份有限公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-110372538-A | The synthetic method of one kind 2,6- dichloro-3-fluorobenzonitrile | 浙江林江化工股份有限公司 | 2019-10-25 | — | — | CN | disclosed |
| WO-2019197407-A1 | PYRIDINE-SUBSTITUTED 2,2'-DI-9H-CARBAZOL-9-YL-[1,1'-BIPHENYL]DICARBONITRILE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN OPTOELECTRONIC APPARATUSES | CYNORA GMBH (DE) | 2019-10-17 | — | — | WO | disclosed |
| CN-104744305-B | A kind of synthetic method of 2,4-bis-chloro-3-cyano group-5-fluobenzoic acid | 浙江中欣氟材股份有限公司 | 2016-08-10 | — | — | CN | disclosed |
| CN-102531961-B | Preparation method of 2,6-dichloro-3-fluorobenzonitrile | UNIV ZHEJIANG TECHNOLOGY | 2014-06-11 | — | — | CN | disclosed |
| WO-2014019609-A1 | METHODS OF PEST CONTROL IN SOYBEAN | SYNGENTA PARTICIPATIONS AG (CH) | 2014-02-06 | — | — | WO | disclosed |
| EP-0635486-B1 | Process for the preparation of fluorobenzonitriles | CLARIANT GMBH (DE) | 1998-12-09 | — | — | EP | disclosed |
| US-5466859-A | Process for preparing fluorobenzonitriles | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-11-14 | — | — | US | disclosed |
| EP-0635486-A2 | Process for the preparation of fluorobenzonitriles | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-01-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220306630-A1 | AGONISTS OF ROR GAMMAt | RORB, RORA, RORC | TRPV4 1162/4885AR 171/4885CYP11B2 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.