Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 12/20 | 0.47 |
| ▸ | HTR2C | P28335 | 4/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 7/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8469856 | 0.94 | DRD2 (0.51) | DRD2SLC6A4HTR2AHTR2CACHE | |
| SCHEMBL8352941 | 0.88 | DRD2 (0.48) | DRD2SLC6A4HTR2AHTR2CACHE | |
| SCHEMBL1545276 | 0.77 | ACHE (0.59) | DRD2SLC6A4HTR2AHTR2CACHE | |
| SCHEMBL8345324 | 0.77 | HTR2A (0.42) | DRD2HTR2AHTR2CHTR7HTR6 | |
| Fumaric Acid SCHEMBL5994470 | 0.77 | DRD2 (0.51) | DRD2SLC6A4HTR2AHTR2CACHE | |
| Hydrochloric Acid SCHEMBL8350496 | 0.76 | HTR2A (0.41) | DRD2HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL8469854 | 0.76 | ACHE (0.57) | DRD2SLC6A4HTR2AACHEHTR1A | |
| SCHEMBL8347635 | 0.76 | DRD2 (0.54) | DRD2SLC6A4HTR2AHTR2CACHE | |
| SCHEMBL7744954 | 0.76 | DRD2 (0.52) | DRD2SLC6A4HTR2AHTR2CACHE | |
| SCHEMBL8345682 | 0.76 | HTR2C (0.57) | DRD2SLC6A4HTR2AHTR2CACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811435-A | 2- (4-heteroaryl-1-piperidinyl)alkyl!-1,3-dioxanes and related compounds and their therapeutic utility | HOECHST MARION RUSSEL, INC. | 1998-09-22 | — | — | US | disclosed |