Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 14/20 | 0.48 |
| ▸ | HTR2C | P28335 | 6/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 7/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8664540 | 0.94 | DRD2 (0.52) | DRD2SLC6A4HTR2AHTR2CACHE | |
| SCHEMBL8352941 | 0.89 | DRD2 (0.48) | DRD2SLC6A4HTR2AHTR2CACHE | |
| SCHEMBL1545276 | 0.79 | ACHE (0.59) | DRD2SLC6A4HTR2AHTR2CACHE | |
| SCHEMBL8469854 | 0.77 | ACHE (0.57) | DRD2SLC6A4HTR2AACHEHTR1A | |
| SCHEMBL7744954 | 0.77 | DRD2 (0.52) | DRD2SLC6A4HTR2AHTR2CACHE | |
| SCHEMBL8345682 | 0.77 | HTR2C (0.57) | DRD2SLC6A4HTR2AHTR2CACHE | |
| SCHEMBL8648906 | 0.77 | DRD2 (0.51) | DRD2SLC6A4HTR2AHTR2CACHE | |
| SCHEMBL8664537 | 0.77 | DRD2 (0.57) | DRD2SLC6A4HTR2AACHEHTR6 | |
| Hydrochloric Acid SCHEMBL8463604 | 0.76 | HTR2C (0.56) | DRD2SLC6A4HTR2AHTR2CACHE | |
| SCHEMBL8347635 | 0.76 | DRD2 (0.54) | DRD2SLC6A4HTR2AHTR2CACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889035-A | 1-(Arylthioalkyl, arylaminoalkyl or arylmethylenealkyl)-3-(heteroaryl) pyrrolidines and related compounds useful as antipsychotics and analgesics | HOECHST MARION ROUSSEL, INC. (US) | 1999-03-30 | — | — | US | disclosed |
| US-5874435-A | PSYCHOLOGICAL DISORDERS; ANALGESICS | HOECHST MARION ROUSSEL, INC. (US) | 1999-02-23 | — | — | US | disclosed |
| US-5854243-A | 3-heteroaryl-1-pyrrolidinealkylthiols and derivatives thereof and their therapeutic utility | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1998-12-29 | — | — | US | disclosed |
| US-5843977-A | (3-heteroaryl-1-pyrrolidinyl) alkoxy!-3,4-dihydro-1(2H)-naphthalenones and related compounds and their therapeutic utility | HOECHST MARION ROSUEEL, INC. | 1998-12-01 | — | — | US | disclosed |
| US-5811435-A | 2- (4-heteroaryl-1-piperidinyl)alkyl!-1,3-dioxanes and related compounds and their therapeutic utility | HOECHST MARION RUSSEL, INC. | 1998-09-22 | — | — | US | disclosed |