Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.77 |
| ▸ | RAB9A | P51151 | 4/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | POLB | P06746 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | CSNK2A2 | P19784 | 7/20 | 0.64 |
| ▸ | CSNK2B | P67870 | 7/20 | 0.64 |
| ▸ | CSNK2A1 | P68400 | 7/20 | 0.64 |
| ▸ | CSNK2A3 | Q8NEV1 | 7/20 | 0.64 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4970562 | 0.75 | MAOB (0.82) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8645195 | 0.75 | LMNA (0.67) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5598444 | 0.73 | NPC1 (0.57) | NPC1RAB9ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL28642133 | 0.73 | POLB (0.70) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL29923723 | 0.73 | POLB (0.70) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3362301 | 0.72 | CHRNB2 (0.64) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4516344 | 0.72 | MAPT (0.52) | NPC1RAB9ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL5598057 | 0.72 | ALDH1A1 (0.61) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4971130 | 0.72 | MAOB (1.00) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL29923932 | 0.72 | KMT2A (0.81) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843947-A | N-pyridyl carboxamides and derivatives | ADIR ET COMPAGNIE (FR) | 1998-12-01 | — | — | US | disclosed |
| US-5712294-A | N-pyridyl carboxamides and derivatives | ADIR ET COMPAGNIE (FR) | 1998-01-27 | — | — | US | disclosed |
| EP-0684241-B1 | N-pyridyl carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1997-08-27 | — | — | EP | disclosed |
| EP-0684241-A1 | N-pyridyl carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-11-29 | — | — | EP | disclosed |