Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.33 |
| ▸ | S100A10 | P60903 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8666186 | 0.87 | CA9 (0.48) | ALDH1A1KDM4ENPC1RAB9ACA12 | |
| SCHEMBL8667540 | 0.79 | CA12 (0.39) | ALDH1A1KDM4ELMNANPC1RAB9A | |
| SCHEMBL8670894 | 0.78 | ALDH1A1 (0.43) | ALDH1A1KDM4ELMNANPC1RAB9A | |
| SCHEMBL8667641 | 0.71 | ADRA1D (0.39) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL10022390 | 0.69 | KDM4E (0.63) | ALDH1A1KDM4ELMNANPC1RAB9A | |
| SCHEMBL8047953 | 0.68 | ADRA1D (0.40) | MEN1KMT2ACA12CA9HDAC1 | |
| SCHEMBL8670248 | 0.68 | L3MBTL1 (0.44) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL8669865 | 0.68 | CA9 (0.52) | ALDH1A1CA12CA9HDAC1HDAC2 | |
| SCHEMBL8047941 | 0.67 | ADRA1D (0.41) | ALDH1A1MEN1KMT2ACA12CA9 | |
| SCHEMBL8670888 | 0.65 | CA12 (0.49) | ALDH1A1KDM4ERAB9ACA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760054-A | BENIGN PROSTATIC HYPERTROPHY | MERCK & CO., INC. (US) | 1998-06-02 | — | — | US | disclosed |
| EP-0755392-A4 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1997-05-02 | — | — | EP | disclosed |
| EP-0755392-A1 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028397-A1 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-10-26 | — | — | WO | disclosed |