Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.39 |
| ▸ | TUBB | P07437 | 2/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8670388 | 0.90 | HDAC1 (0.46) | L3MBTL1HDAC1HDAC2HDAC3HDAC7 | |
| SCHEMBL8670252 | 0.86 | ADRA1D (0.53) | L3MBTL1HDAC1HDAC2ADRA1DADRA1A | |
| SCHEMBL8047949 | 0.84 | CHRM5 (0.38) | — | |
| SCHEMBL8667641 | 0.83 | ADRA1D (0.39) | HDAC1HDAC2HDAC3HDAC7HDAC6 | |
| SCHEMBL8667501 | 0.81 | ADRA1D (0.39) | HDAC1HDAC2HDAC3ADRA1DADRA1A | |
| SCHEMBL8047953 | 0.81 | ADRA1D (0.40) | HDAC1HDAC2HDAC3HDAC7HDAC6 | |
| SCHEMBL8670390 | 0.79 | HDAC1 (0.53) | HDAC1HDAC2ADRA1DADRA1AADRA1B | |
| SCHEMBL8047931 | 0.77 | CA9 (0.51) | HDAC1HDAC2HTR1ADRD2HTR2A | |
| SCHEMBL8671281 | 0.77 | HDAC1 (0.49) | HDAC1HDAC2ADRA1DADRA1AADRA1B | |
| SCHEMBL8670894 | 0.77 | ALDH1A1 (0.43) | L3MBTL1HDAC1HDAC2HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760054-A | BENIGN PROSTATIC HYPERTROPHY | MERCK & CO., INC. (US) | 1998-06-02 | — | — | US | disclosed |
| EP-0755392-A4 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1997-05-02 | — | — | EP | disclosed |
| EP-0755392-A1 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028397-A1 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-10-26 | — | — | WO | disclosed |