SCHEMBL8667748

SCHEMBL8667748

CSc1cc(Cl)nc(OCc2ccccc2)n1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIN1 Q13526 1/20 0.40
TSHR P16473 3/20 0.39
PRMT5 O14744 1/20 0.39
PIK3C3 Q8NEB9 1/20 0.39
STAT3 P40763 1/20 0.38
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ALOX5 P09917 1/20 0.38
LMNA P02545 1/20 0.38
L3MBTL1 Q9Y468 3/20 0.38
CNR1 P21554 1/20 0.38
CASP3 P42574 1/20 0.37
RAB9A P51151 1/20 0.37
SENP8 Q96LD8 1/20 0.37
SENP7 Q9BQF6 1/20 0.37
SENP6 Q9GZR1 1/20 0.37
MAOB P27338 1/20 0.36
RXRA P19793 1/20 0.36
RXRB P28702 1/20 0.36
RXRG P48443 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8871531 0.89 ALOX5 (0.43) PIN1TSHRSTAT3HTTSMN1; SMN2
SCHEMBL8664742 0.86 PIN1 (0.39) PIN1TSHRPRMT5PIK3C3STAT3
SCHEMBL8670167 0.84 PIN1 (0.48) PIN1TSHRPRMT5PIK3C3STAT3
SCHEMBL8133910 0.82 MPO (0.43) TSHRSTAT3HTTSMN1; SMN2ALOX5
SCHEMBL8665281 0.80 ALDH1A1 (0.49) PIN1TSHRPRMT5PIK3C3STAT3
SCHEMBL8384805 0.78 PIN1 (0.47) PIN1PRMT5PIK3C3ALOX5NUDT1
SCHEMBL8669771 0.78 ALDH1A1 (0.53) PIN1TSHRPRMT5PIK3C3HTT
SCHEMBL6639567 0.77 MPO (0.49) PIN1TSHRPRMT5PIK3C3SMN1; SMN2
SCHEMBL8558770 0.73 ALOX5 (0.48) TSHRHTTSMN1; SMN2ALOX5LMNA
SCHEMBL11009131 0.73 TSHR (0.52) PIN1TSHRSTAT3HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5723412-A HERBICIDES KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1998-03-03 US disclosed
EP-0694538-A2 2-benzyloxy-4-phenoxypyrimidine derivative, processes for producing the derivative and herbicidal composition containing the derivative KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1996-01-31 EP disclosed