SCHEMBL8667968

SCHEMBL8667968

CCC(=O)NC1CCc2cc([N+](=O)[O-])ccc21

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.48
CA7 P43166 3/20 0.48
CA14 Q9ULX7 3/20 0.48
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
CA9 Q16790 2/20 0.45
KMT2A Q03164 3/20 0.45
MEN1 O00255 1/20 0.45
ALDH1A1 P00352 1/20 0.43
HTT P42858 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
HTR1A P08908 1/20 0.42
HTR2A P28223 1/20 0.42
KCNH2 Q12809 1/20 0.42
MTNR1A P48039 1/20 0.41
MTNR1B P49286 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
GRIN2B Q13224 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7795529 0.82 SIRT2 (0.46) KMT2AMEN1ALDH1A1
SCHEMBL30471759 0.80 CA12 (0.53) CA12CA7CA14CA1CA2
SCHEMBL1787681 0.79 CA12 (0.49) CA12CA7CA14CA1CA2
SCHEMBL4107613 0.79 MTNR1A (0.62) CA12CA7CA14CA1CA2
SCHEMBL4107609 0.79 MTNR1A (0.62) CA12CA7CA14CA1CA2
SCHEMBL24120 0.78 CA12 (0.48) CA12CA7CA14CA1CA2
SCHEMBL32008 0.77 CA12 (0.47) CA12CA7CA14CA1CA2
SCHEMBL1787459 0.76 CYP11B2 (0.56) CA12CA7CA14CA1CA2
SCHEMBL17335683 0.76 ALDH1A1 (0.61) KMT2AMEN1ALDH1A1HTTMTNR1A
SCHEMBL7445856 0.76 ALDH1A1 (0.61) KMT2AMEN1ALDH1A1HTTMTNR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5721234-A TREATING CONVULSIONS, ANXIETY, CEREBRAL HYPOXIA/ISCHEMIA, PARKINSON*S DISEASE WARNER-LAMBERT COMPANY (US) 1998-02-24 US disclosed
WO-1996017832-A1 NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYLQUINOXALINEDIONES WARNER-LAMBERT COMPANY (US) 1996-06-13 WO disclosed