Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 15/20 | 0.55 |
| ▸ | CCKAR | P32238 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | OXTR | P30559 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8803196 | 0.92 | CCKBR (0.47) | CCKBRCCKAROPRK1PDE4DKCNH2 | |
| SCHEMBL8669229 | 0.90 | CCKBR (0.57) | CCKBRCCKARLMNA | |
| SCHEMBL8669189 | 0.89 | CCKBR (0.58) | CCKBRCCKAR | |
| SCHEMBL8801767 | 0.82 | BRD4 (0.41) | CCKBRLMNAOPRK1PDE3AHTR2B | |
| SCHEMBL8667987 | 0.80 | HTR2B (0.51) | CCKBRCCKARLMNAOPRK1PDE3A | |
| SCHEMBL26334401 | 0.80 | OPRK1 (0.48) | CCKBRLMNAOPRK1PDE3AHTR2B | |
| SCHEMBL31629832 | 0.80 | OPRK1 (0.48) | CCKBRLMNAOPRK1PDE3AHTR2B | |
| SCHEMBL25411419 | 0.80 | CCKBR (0.56) | CCKBRLMNAOPRK1PDE3AHTR2B | |
| SCHEMBL25411426 | 0.80 | CCKBR (0.56) | CCKBRLMNAOPRK1PDE3AHTR2B | |
| SCHEMBL31366502 | 0.80 | CCKBR (0.56) | CCKBRLMNAOPRK1PDE3AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843941-A | Ras farnesyl transferase inhibitors | GENENTECH, INC. (US) | 1998-12-01 | — | — | US | disclosed |
| EP-0763537-A2 | Non-peptidyl Ras farnesyl transferase inhibitors | GENENTECH, INC. (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0698015-A1 | PREPARATION OF N-CYANODITHIOIMINO-CARBONATES AND 3-MERCAPTO-5-AMINO-1H-1,2,4-TRIAZOLE | GENENTECH, INC. (US) | 1996-02-28 | — | — | EP | disclosed |
| WO-1994026723-A2 | ras FARNESYL TRANSFERASE INHIBITORS | GENENTECH, INC. (US) | 1994-11-24 | — | — | WO | disclosed |