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SCHEMBL8669229

SCHEMBL8669229

CC(C)(C)OC(=O)CNC1N=C(c2ccccc2F)c2cc(Cl)ccc2N(CC(=O)O)C1=O

nearest known ligand 0.57

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ CCKBR P32239 9/20 0.57
▸ CCKAR P32238 6/20 0.57
▸ LMNA P02545 1/20 0.43
▸ POLB P06746 1/20 0.43
▸ MAPT P10636 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8803196 0.92 CCKBR (0.47) CCKBRCCKAR
SCHEMBL8667990 0.90 CCKBR (0.55) CCKBRCCKARLMNA
SCHEMBL8800940 0.89 CCKBR (0.64) CCKBRCCKARLMNAPOLBMAPT
SCHEMBL8804138 0.83 CCKBR (0.42) CCKBRCCKAR
SCHEMBL8669226 0.81 CCKBR (0.50) CCKBRCCKARLMNAPOLBMAPT
SCHEMBL8669189 0.81 CCKBR (0.58) CCKBRCCKAR
SCHEMBL8801216 0.76 CCKBR (0.39) CCKBRCCKARMAPT
SCHEMBL8801767 0.76 BRD4 (0.41) CCKBRLMNAMAPT
SCHEMBL8800433 0.74 CCKBR (0.46) CCKBRCCKAR
SCHEMBL7544921 0.73 CCKBR (0.54) CCKBRCCKAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5843941-A Ras farnesyl transferase inhibitors GENENTECH, INC. (US) 1998-12-01 — — US disclosed
EP-0763537-A2 Non-peptidyl Ras farnesyl transferase inhibitors GENENTECH, INC. (US) 1997-03-19 — — EP disclosed
WO-1994026723-A2 ras FARNESYL TRANSFERASE INHIBITORS GENENTECH, INC. (US) 1994-11-24 — — WO disclosed