SCHEMBL8668308

SCHEMBL8668308

COC(=O)CSc1cccc(N=C=O)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.49
KDM4E B2RXH2 2/20 0.49
GLA P06280 2/20 0.49
CYP2C19 P33261 2/20 0.49
GAA P10253 2/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2C9 P11712 1/20 0.49
HSD17B10 Q99714 5/20 0.46
ALDH1A1 P00352 4/20 0.46
HPGD P15428 4/20 0.46
TP53 P04637 1/20 0.46
MAPK1 P28482 3/20 0.41
ALOX15 P16050 2/20 0.41
RXFP1 Q9HBX9 1/20 0.41
POLB P06746 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
LMNA P02545 1/20 0.38
APEX1 P27695 1/20 0.37
CYP2D6 P10635 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9063136 0.82 APEX1 (0.55) KDM4ECYP2C19GAACYP1A2HSD17B10
SCHEMBL2651634 0.77 GABRA1 (0.42) CYP1A2CYP3A4MAPK1APEX1
SCHEMBL13949073 0.76 ALDH1A1 (0.53) MAPTKDM4EGLACYP2C19GAA
SCHEMBL8147162 0.76 LMNA (0.54) MAPTKDM4EGLACYP2C19GAA
SCHEMBL8668257 0.75 SLC7A5 (0.49) MAPTKDM4ECYP2C19GAACYP1A2
SCHEMBL2070354 0.75 TRPM5 (0.53) MAPTKDM4EGLACYP2C19GAA
SCHEMBL2069582 0.75 MAPT (0.51) MAPTKDM4EGLACYP2C19GAA
SCHEMBL8667113 0.75 MAPT (0.51) MAPTKDM4EGLACYP2C19GAA
SCHEMBL11530319 0.74 MAPK1 (0.38) CYP1A2CYP3A4MAPK1APEX1
SCHEMBL7663822 0.74 APEX1 (0.69) MAPTKDM4EGLACYP2C19GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5707991-A TREATMENT OF NERVOUS SYSTEM DISORDERS, PARKINSON'S DISEASE RHONE-POULENC RORER S.A. (FR) 1998-01-13 US disclosed