SCHEMBL8669703

SCHEMBL8669703

NC(=O)c1cccc(C(=O)O)c1-c1ccc2ccccc2c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.55
CYP2D6 P10635 1/20 0.55
CYP2C9 P11712 1/20 0.55
TSHR P16473 1/20 0.55
CYP2C19 P33261 1/20 0.55
SOS1 Q07889 1/20 0.55
HIF1A Q16665 1/20 0.55
FABP3 P05413 1/20 0.54
FABP4 P15090 1/20 0.54
FABP5 Q01469 1/20 0.54
ACMSD Q8TDX5 1/20 0.54
KDM4E B2RXH2 2/20 0.50
ALDH1A1 P00352 2/20 0.50
GAA P10253 1/20 0.50
PARP1 P09874 3/20 0.48
FTO Q9C0B1 1/20 0.46
WDR5 P61964 1/20 0.45
IDO1 P14902 1/20 0.45
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9009356 0.92 ACMSD (0.62) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL16670765 0.84 CYP2C9 (0.55) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL8669706 0.79 ACMSD (0.51) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL8948602 0.79 PTPN1 (0.57) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL8030330 0.78 CYP1A2 (0.51) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL27533883 0.78 ACMSD (0.57) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL30874069 0.78 WDR5 (0.71) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL31621279 0.77 SLC6A2 (0.64) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL31621280 0.77 SLC6A2 (0.64) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL8949874 0.76 DHODH (0.46) CYP1A2CYP2D6CYP2C9TSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020138011-A1 TEREPHTHALIC ACID DERIVATIVE HAVING RING-FUSED STRUCTURE 第一三共株式会社 2020-07-02 WO disclosed
EP-0876330-A1 ARYL OR HETEROARYL AMIDES OF TETRAHYDRONAPHTHALENE, CHROMAN, THIOCHROMAN AND 1,2,3,4-TETRAHYDROQUINOLINE CARBOXYLIC ACIDS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY Allergan (US) 1998-11-11 EP disclosed
WO-1997019052-A1 ARYL OR HETEROARYL AMIDES OF TETRAHYDRONAPHTHALENE, CHROMAN, THIOCHROMAN AND 1,2,3,4-TETRAHYDROQUINOLINE CARBOXYLIC ACIDS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY ALLERGAN (US) 1997-05-29 WO disclosed