SCHEMBL8670388

SCHEMBL8670388

COc1ccc2c(c1)S(O)(O)N(CCCCBr)C2=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 6/20 0.46
HDAC2 Q92769 6/20 0.46
ELANE P08246 1/20 0.43
CA12 O43570 2/20 0.41
CA9 Q16790 2/20 0.41
CA1 P00915 1/20 0.41
HTR1A P08908 2/20 0.41
DRD2 P14416 2/20 0.41
HTR2A P28223 1/20 0.41
HTR7 P34969 1/20 0.41
HTR6 P50406 1/20 0.41
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
PAX8 Q06710 1/20 0.40
ALDH1A1 P00352 4/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
HDAC3 O15379 3/20 0.39
HDAC4 P56524 3/20 0.39
HDAC7 Q8WUI4 3/20 0.39
HDAC8 Q9BY41 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8670248 0.90 L3MBTL1 (0.44) HDAC1HDAC2ELANECA12CA9
SCHEMBL8670390 0.86 HDAC1 (0.53) HDAC1HDAC2ELANECA12CA9
SCHEMBL8667683 0.81 HDAC1 (0.38) HDAC1HDAC2CA12CA9CA1
SCHEMBL8670252 0.79 ADRA1D (0.53) HDAC1HDAC2CA12CA9CA1
SCHEMBL8047912 0.78 L3MBTL1 (0.38) HDAC1HDAC2CA12CA9NPC1
SCHEMBL8047931 0.77 CA9 (0.51) HDAC1HDAC2ELANECA12CA9
SCHEMBL8668118 0.77 HDAC1 (0.57) HDAC1HDAC2CA12CA9CA1
SCHEMBL8667641 0.75 ADRA1D (0.39) HDAC1HDAC2CA12CA9CA1
SCHEMBL8668865 0.73 ELANE (0.41) HDAC1HDAC2ELANECA12CA9
SCHEMBL8667501 0.73 ADRA1D (0.39) HDAC1HDAC2CA12CA9CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5760054-A BENIGN PROSTATIC HYPERTROPHY MERCK & CO., INC. (US) 1998-06-02 US disclosed
EP-0755392-A4 ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO INC (US) 1997-05-02 EP disclosed
EP-0755392-A1 ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO. INC. (US) 1997-01-29 EP disclosed
WO-1995028397-A1 ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1995-10-26 WO disclosed