Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | GNPAT | O15228 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8671445 | 0.85 | KDM4E (0.39) | ALOX15KDM4EMAPTTHRBNFKB1 | |
| SCHEMBL8668912 | 0.83 | ALOX15 (0.39) | ALOX15KDM4EMAPTTHRBNFKB1 | |
| SCHEMBL8668238 | 0.81 | TACR1 (0.43) | ALOX15KDM4EMAPTTHRBNFKB1 | |
| SCHEMBL8669962 | 0.76 | TNF (0.39) | ALOX15KDM4EMAPTTHRBNFKB1 | |
| SCHEMBL8674201 | 0.75 | TNF (0.43) | ALOX15TNFLMNAEGFRSRC | |
| SCHEMBL4575645 | 0.70 | TACR1 (0.59) | ALOX15SMN1; SMN2TNFTACR1CTSS | |
| SCHEMBL21411538 | 0.69 | KEAP1 (0.56) | MAPTSMN1; SMN2TNFTACR1MTNR1A | |
| SCHEMBL3278174 | 0.69 | LMNA (0.52) | ALOX15KDM4EMAPTTHRBNFKB1 | |
| SCHEMBL3278180 | 0.69 | LMNA (0.52) | ALOX15KDM4EMAPTTHRBNFKB1 | |
| SCHEMBL7362451 | 0.67 | CYP2C19 (0.60) | ALOX15KDM4EMAPTTHRBNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849781-A | Tricyclic amides | ADIR ET COMPAGNIE (FR) | 1998-12-15 | — | — | US | disclosed |
| US-5712312-A | MELATONINERGIC RECEPTOR LIGANDS, TREATMENT OF SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-01-27 | — | — | US | disclosed |