Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 3/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.38 |
| ▸ | ITGAL | P20701 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 3/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8670193 | 0.85 | MTNR1A (0.42) | TNFALOX15MTNR1AMTNR1BEGFR | |
| SCHEMBL8668930 | 0.83 | MTNR1A (0.60) | TNFALOX15MTNR1AMTNR1BEGFR | |
| SCHEMBL8671978 | 0.81 | ALOX15 (0.57) | TNFALOX15ACETACR1ITGB2 | |
| SCHEMBL8669962 | 0.76 | TNF (0.39) | TNFALOX15MTNR1AMTNR1BEGFR | |
| SCHEMBL8672201 | 0.75 | ALOX15 (0.39) | TNFALOX15MTNR1AMTNR1BEGFR | |
| Acetyltryptophan SCHEMBL702442 | 0.70 | ALOX15 (0.79) | ALOX15ACETACR1ITGB2ICAM1 | |
| Acetyltryptophan SCHEMBL57141 | 0.70 | ALOX15 (0.79) | ALOX15ACETACR1ITGB2ICAM1 | |
| Acetyltryptophan SCHEMBL29360698 | 0.70 | ALOX15 (0.79) | ALOX15ACETACR1ITGB2ICAM1 | |
| Acetyltryptophan SCHEMBL29401158 | 0.70 | ALOX15 (0.79) | ALOX15ACETACR1ITGB2ICAM1 | |
| Acetyltryptophan SCHEMBL4216450 | 0.70 | ALOX15 (0.79) | ALOX15ACETACR1ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849781-A | Tricyclic amides | ADIR ET COMPAGNIE (FR) | 1998-12-15 | — | — | US | disclosed |
| US-5712312-A | MELATONINERGIC RECEPTOR LIGANDS, TREATMENT OF SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-01-27 | — | — | US | disclosed |