Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | PNP | P00491 | 3/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8670120 | 0.88 | TYMS (0.39) | HIF1ALTB4RCCR2CCR5BACE1 | |
| SCHEMBL8673158 | 0.80 | HIF1A (0.49) | HIF1ACCR2CCR5PNPALDH1A1 | |
| SCHEMBL8801326 | 0.78 | ACHE (0.45) | — | |
| SCHEMBL1123622 | 0.74 | KMT2A (0.46) | BACE1PNPSMN1; SMN2KDM4EABL1 | |
| SCHEMBL9200181 | 0.72 | AGTR1 (0.40) | TLR8TSHRKDM4EALDH1A1MAPT | |
| SCHEMBL9276461 | 0.71 | PSMB5 (0.35) | CCR2CCR5 | |
| SCHEMBL9423837 | 0.71 | MAPT (0.38) | HIF1ASMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL8670123 | 0.68 | HIF1A (0.49) | HIF1ACCR2CCR5PNPALDH1A1 | |
| SCHEMBL9424129 | 0.64 | TLR8 (0.34) | CCR2CCR5TLR8 | |
| SCHEMBL320046 | 0.64 | CA2 (0.54) | HIF1ATP53SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5804583-A | Pyrimidinone derivatives fused to nitrogen heterocycles having a II antagonistic activity | ISTITUTO LUSO FARMACO D'ITALIA (IT) | 1998-09-08 | — | — | US | disclosed |
| EP-0680480-B1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY | LUSO FARMACO INST (IT) | 1997-07-30 | — | — | EP | disclosed |
| EP-0680480-A1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY. | LUSO FARMACO INST (IT) | 1995-11-08 | — | — | EP | disclosed |
| WO-1994017067-A1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1994-08-04 | — | — | WO | disclosed |