Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9423387 | 0.86 | HPGD (0.35) | TLR8CCR2CCR5 | |
| SCHEMBL9423813 | 0.83 | HPGD (0.35) | TLR8 | |
| SCHEMBL9423777 | 0.79 | TLR7 (0.37) | — | |
| SCHEMBL9423837 | 0.76 | MAPT (0.38) | — | |
| SCHEMBL8673158 | 0.72 | HIF1A (0.49) | CCR2CCR5 | |
| SCHEMBL1187437 | 0.72 | HPGD (0.35) | TLR8 | |
| SCHEMBL9424313 | 0.71 | CCR2 (0.40) | CCR2CCR5 | |
| SCHEMBL320046 | 0.68 | CA2 (0.54) | SKP2 | |
| SCHEMBL1187263 | 0.66 | MEN1 (0.40) | TLR8 | |
| SCHEMBL1187550 | 0.65 | ALDH1A1 (0.42) | TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5324729-A | Hypotensive agents | MERCK & CO., INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0522038-A4 | SUBSTITUTED PYRIMIDINES, PYRIMIDINONES AND PYRIDOPYRIMIDINES | — | 1993-05-26 | — | — | EP | disclosed |
| EP-0522038-A1 | SUBSTITUTED PYRIMIDINES, PYRIMIDINONES AND PYRIDOPYRIMIDINES | MERCK & CO. INC. (US) | 1993-01-13 | — | — | EP | disclosed |
| US-5166206-A | Hypotensive agents, central nervous system disorders, glaucoma or angiotensin antagonist | MERCK & CO., INC. (US) | 1992-11-24 | — | — | US | disclosed |
| WO-1991015209-A1 | SUBSTITUTED PYRIMIDINES, PYRIMIDINONES AND PYRIDOPYRIMIDINES | MERCK & CO., INC. (US) | 1991-10-17 | — | — | WO | disclosed |